LOH by regions

• 4q21.23-22.1 LOH
  15 March 2015

  Pathology
  Loss of 4q21.23-22.1 is a prognostic marker for disease free and overall survival in non-small cell lung cancer. (#25501003#)
  See also
  4q21.23-22.1
  Open References
  Loss of 4q21.23-22.1 is a prognostic marker for disease free and overall survival in non-small cell lung cancer. Uzunoglu FG, Dethlefsen E, Hanssen A, Wrage M, Deutsch L, Harms-Effenberger K, Vashist YK, Reeh M, Sauter G, Simon R, Bockhorn M, Pantel K, Izbicki JR, Wikman H. PLoS One. 2014 Dec 11;9(12):e113315. (...)

• 20q copy-neutral LOH
  28 November 2011

  Pathology
  Increased frequency of 20q gain and copy-neutral loss of heterozygosity in mismatch repair proficient familial colorectal carcinomas. (#21445971#)
  References
  Increased frequency of 20q gain and copy-neutral loss of heterozygosity in mismatch repair proficient familial colorectal carcinomas. Middeldorp A, van Eijk R, Oosting J, Forte GI, van Puijenbroek M, van Nieuwenhuizen M, Corver WE, Ruano D, Caldes T, Wijnen J, Morreau H, van Wezel T. Int J Cancer. 2011 Mar 28. PMID: (...)

• 19q LOH
  28 November 2011

  Pathology
  19q13 LOH
  Tumors
  glial tumors oligodendroglioma
  References
  Detection of allelic status of 1p and 19q by microsatellite-based PCR versus FISH: limitations and advantages in application to patient management. Jha P, Sarkar C, Pathak P, Sharma MC, Kale SS, Gupta D, Chosdol K, Suri V. Diagn Mol Pathol. 2011 Mar;20(1):40-7. PMID: #21326038#

• 22q11 LOH
  19 May 2008

  Tumors
  meningiomas (#18474292#)
  Target genes
  BCR (breakpoint cluster region)
  RAB36 (a member of RAS oncogene family)
  GNAZ [guanine nucleotide binding protein (G protein), alpha-z polypeptide]
  RTDR1 (rhabdoid tumor deletion region gene 1)
  References
  Wozniak K, Piaskowski S, Gresner SM, Golanska E, Bieniek E, Bigoszewska K, Sikorska B, Szybka M, Kulczycka-Wojdala D, Zakrzewska M, Zawlik I, Papierz W, Stawski R, Jaskolski DJ, Och W, Sieruta M, Liberski PP, Rieske P. BCR (...)

• 21q11-21 LOH
  1 February 2008

  Tumors
  pulmonary squamous cell carcinoma (bronchial squamous cell carcinoma) (#10612803#)
  References
  Groet, J.; Ives, J. H.; Jones, T. A.; Danton, M.; Flomen, R. H.; Sheer, D.; Hrascan, R.; Pavelic, K.; Nizetic, D. : Narrowing of the region of allelic loss in 21q11-21 in squamous non-small cell lung carcinoma and cloning of a novel ubiquitin-specific protease gene from the deleted segment. Genes Chromosomes Cancer 27: 153-161, 2000. PubMed ID : (...)

• 8p22-p23 LOH
  18 September 2007

  Tumors
  prostatic adenocarcinoma (#16470536#) Allelic loss at 8p22-p23 was significantly more frequent in clinical prostate cancer (CPC) than in incidental prostate cancer and in pT4 CPC than in earlier-stage CPC. (#16470536#) Deletion of 8p is an important event in both the initiation and metastasis of prostate cancer. The extremely high frequency of LOH at 8p22-23.1 in high-grade tumors suggests the existence of a novel putative tumor-suppressor gene associated with the progression of (...)

• Chr.8 LOH
  17 September 2007

  Tumors
  mammary carcinomas (breast cancer)
  References
  Seitz S, Korsching E, Weimer J, Jacobsen A, Arnold N, Meindl A, Arnold W, Gustavus D, Klebig C, Petersen I, Scherneck S. Genetic background of different cancer cell lines influences the gene set involved in chromosome 8 mediated breast tumor suppression. Genes Chromosomes Cancer. 2006 Jun;45(6):612-27. PMID: #16552773#

• 3p12 LOH
  16 September 2007

  Homozygous deletions or loss of heterozygosity (LOH) at human chromosome band 3p12 are consistent features of lung and other malignancies, suggesting the presence of a tumor suppressor gene(s) (TSG) at this location.
  Target genes
  ROBO1 (or DUTT1 (Deleted in U Twenty Twenty), FLJ21882, SAX3) ROBO1 (DUTT1), the human ortholog of the fly gene ROBO, has homology with NCAM proteins. Extensive analyses of ROBO1 in lung cancer have not revealed any mutations, suggesting that another gene(s) at (...)

• 1p22.3 LOH
  10 September 2007

  Tumors
  mantle cell lymphoma (#16830336#)
  Target genes
  SH3GLB1
  BCL10
  CLCA2
  References
  Balakrishnan A, von Neuhoff N, Rudolph C, Kamphues K, Schraders M, Groenen P, van Krieken JH, Callet-Bauchu E, Schlegelberger B, Steinemann D. Quantitative microsatellite analysis to delineate the commonly deleted region 1p22.3 in mantle cell lymphomas. Genes Chromosomes Cancer. 2006 Oct;45(10):883-92. PMID: (...)

• 1p36-pter LOH
  9 September 2007

  Tumors
  germ cell tumors (#16897744#)
  References
  Zahn S, Sievers S, Alemazkour K, Orb S, Harms D, Schulz WA, Calaminus G, Gobel U, Schneider DT. Imbalances of chromosome arm 1p in pediatric and adult germ cell tumors are caused by true allelic loss: a combined comparative genomic hybridization and microsatellite analysis. Genes Chromosomes Cancer. 2006 Nov;45(11):995-1006. PMID: (...)

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