LOH by regions

• 2q37 LOH
  20 April 2007

  Tumors
  Wilms tumor (5%)
  oral squamous cell carcinoma (OSCC) (2q37.3)
  Candidate genes
  LRP1B, CASP8, CASP10, BARD1, ILKAP, PPP1R7, and ING5
  References
  Cengiz B, Gunduz M, Nagatsuka H, Beder L, Gunduz E, Tamamura R, Mahmut N, Fukushima K, Ali MA, Naomoto Y, Shimizu K, Nagai N. Fine deletion mapping of chromosome 2q21-37 shows three preferentially deleted regions in oral cancer. Oral Oncol. 2007 Mar;43(3):241-7. Epub 2006 Jul 20. PMID: #16857411#
  Beder LB, Gunduz M, Ouchida M, (...)

• 9q21-q31 LOH
  15 February 2007

  Tumors
  basal cell carcinoma (93%) (#16204023#)
  See also
  Oncobase regional LOH 9q LOH
  Oncogen

• 7q22-q31 LOH
  13 February 2007

  Tumors
  uterine leiomyomas (#17285575#)
  See also
  7q deletion 7q22-q31 deletion
  References
  Vanharanta S, Wortham NC, Langford C, El-Bahrawy M, van der Spuy Z, Sjoberg J, Lehtonen R, Karhu A, Tomlinson IP, Aaltonen LA. Definition of a minimal region of deletion of chromosome 7 in uterine leiomyomas by tiling-path microarray CGH and mutation analysis of known genes in this region. Genes Chromosomes Cancer. 2007 Feb 6; PMID: (...)

• 3p LOH
  7 February 2007

  References
  Tai AL, Mak W, Ng PK, Chua DT, Ng MY, Fu L, Chu KK, Fang Y, Qiang Song Y, Chen M, Zhang M, Sham PC, Guan XY. High-throughput loss-of-heterozygosity study of chromosome 3p in lung cancer using single-nucleotide polymorphism markers. Cancer Res. 2006 Apr 15;66(8):4133-8. PMID: #16618734#

• 16q24 LOH
  31 January 2007

  Tumors
  retinoblastoma (#17210724#) vitreous tumoral seeding (#17210724#)
  References
  Gratias S, Rieder H, Ullmann R, Klein-Hitpass L, Schneider S, Boloni R, Kappler M, Lohmann DR. Allelic loss in a minimal region on chromosome 16q24 is associated with vitreous seeding of retinoblastoma. Cancer Res. 2007 Jan 1;67(1):408-16. PMID: #17210724#

• 3p21 LOH
  17 January 2007

  The early and frequent occurrence of deletions at 3p21.3 in lung cancer has led to the consideration of this chromosomal region as a lung cancer (LUCA) critical region with tumor suppressor activity.
  Tumors
  pulmonary carcinomas
  prostatic carcinomas (prostate cancer)
  Candidate genes
  MLH1
  Subregion
  3p21.3 LOH

• 6q25 LOH
  17 January 2007

  Tumors
  pulmonary carcinomas (65%)
  pediatric intracranial ependymomas (#18328946#)
  Regions
  6q25.1 LOH in sporadic lung cancer patients (65%)
  6q25.3 deletion in pediatric intracranial ependymomas (#18328946#)
  Candidate genes
  p34
  See also
  6q25 region
  References
  Monoranu CM, Huang B, Zangen IL, Rutkowski S, Vince GH, Gerber NU, Puppe B, Roggendorf W. Correlation between 6q25.3 deletion status and survival in pediatric intracranial ependymomas. Cancer Genet Cytogenet. 2008 Apr (...)

• 17q22-24 LOH
  11 May 2006

  Candidate genes
  PRKAR1A
  Tumors
  adrenocortical tumors somatic PRKAR1A mutations

• Chr.10 LOH
  14 March 2006

  Tumors
  uterine leiomyosarcoma
  glioblastoma multiforme
  Subregions
  LOH 10q glioblastoma multiforme
  See also
  LOH regions
  Oncobase

• 9p LOH
  14 March 2006

  Regions
  9p13 LOH
  9p21 LOH
  Tumors
  acute lymphoblastic leukemia
  leiomyosarcoma
  esophageal squamous cell carcinoma
  Candidate genes
  CDKN2A
  CDKN2B
  See also
  LOHs

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