LOH by regions

• 11q22-q24 LOH
  20 June 2005

  Tumors
  pulmonary carcinomas
  colonic carcinomas
  mammary carcinomas
  cervical carcinomas
  head and neck carcinomas
  Candidate genes
  PPP2R1B (PPA2)

• 11q LOH
  20 June 2005

  Tumors
  Wilms tumor (#17099873#, #16518847#)
  pulmonary carcinomas
  colorectal adenocarcinomas (colorectal cancer)
  mammary carcinomas (breast cancer) ( 60%)
  cervical squamous cell carcinoma
  head and neck squamous cell carcinoma (HNSCC) ( 60%)
  ovarian carcinomas ( 60%)
  Localization
  11q22-q24 LOH
  pulmonary carcinomas
  colonic carcinomas
  mammary carcinomas
  cervical carcinomas
  head and neck carcinomas (#17492757#)
  See also
  11q loss (CGH)
  11q deletion (Cytogenetics) (...)

• 1p36 LOH
  18 June 2005

  Tumors
  neuroblastomas (1p36.3 LOH) (25%)
  gliomas oligodendroglioma astrocytomas
  pheochromocytomas (67%)
  paragangliomas (50%)
  hepatocellular carcinoma
  Candidate genes
  PRDM2 (RIZ1)
  SHREW1
  KCNAB2
  CHD5
  CAMTA1 (#17222547#)
  FLJ10737 (#17222547#)
  ARID1A (#17492758#)
  Subregions
  1p36.11 LOH
  1p36.3 LOH
  References
  1p36 tumor suppression—a matter of dosage? Henrich KO, Schwab M, Westermann F. Cancer Res. 2012 Dec 1;72(23):6079-88. doi: 10.1158/0008-5472.CAN-12-2230 . (...)

• 9q LOH
  18 June 2005

  Regions
  9q22.3 LOH: PTCH1 medulloblastoma
  9q21-q31 LOH (93%) (#16204023#) basal cell carcinoma (#16204023#)
  See also
  regional LOH
  Oncobase
  Oncogen

• 10q LOH
  18 June 2005

  Loci
  10q24-q25 LOH: SUFU medulloblastoma
  Tumors
  glioblastoma (69%)
  anaplastic oligodendroglioma
  medulloblastoma (SUFU locus at 10q24-q25)
  Driver genes
  PTEN at 10q23
  See also
  Oncobase

• LOH detection by SNPs
  19 May 2005

  References
  Dutt A, Beroukhim R. Single nucleotide polymorphism array analysis of cancer. Curr Opin Oncol. 2007 Jan;19(1):43-9. PMID: #17133111#
  Tai AL, Mak W, Ng PK, Chua DT, Ng MY, Fu L, Chu KK, Fang Y, Qiang Song Y, Chen M, Zhang M, Sham PC, Guan XY. High-throughput loss-of-heterozygosity study of chromosome 3p in lung cancer using single-nucleotide polymorphism markers. Cancer Res. 2006 Apr 15;66(8):4133-8. PMID: #16618734#
  Lips EH, Dierssen JW, van Eijk R, Oosting J, Eilers PH, (...)

• SNPs allelotyping
  19 May 2005

  References
  Dutt A, Beroukhim R. Single nucleotide polymorphism array analysis of cancer. Curr Opin Oncol. 2007 Jan;19(1):43-9. PMID: #17133111#
  Janne PA, Li C, Zhao X, Girard L, Chen TH, Minna J, Christiani DC, Johnson BE, Meyerson M. High-resolution single-nucleotide polymorphism array and clustering analysis of loss of heterozygosity in human lung cancer cell lines. Oncogene. 2004 Apr 8;23(15):2716-26. PMID: #15048096#
  Hoque MO, Lee CC, Cairns P, Schoenberg M, Sidransky D. (...)

• 15q13.2-q21.1 LOH
  6 November 2004

  Tumors
  urothelial carcinoma (39%)

• 16q LOH
  19 October 2004

  Tumors
  Wilms tumor (nephroblastoma)
  mammary carcinomas (breast cancer) (#16518845#) Loss of heterozygosity on the long arm of chromosome 16 is one of the most frequent genetic events in breast cancer, suggesting the presence of one or more classic tumor-suppressor genes (TSGs).
  Candidate genes
  E-cadherin
  References
  Wittmann S, Zirn B, Alkassar M, Ambros P, Graf N, Gessler M. Loss of 11q and 16q in Wilms tumors is associated with anaplasia, tumor recurrence, and poor prognosis. (...)

• 11p15.5 LOH
  18 October 2004

  Tumors
  Wilms tumor (30%)
  hepatoblastoma
  embryonal rhabdomyosarcoma
  pancreatoblastoma
  parathyroid tumors
  Target genes
  H19
  P57KIP2
  See also
  IGF2

0 | 10 | 20 | 30 | 40 | 50 | 60