Home > G. Tumoral pathology > Molecular pathology of tumors > Genetic anomalies > LOH by regions > 11q LOH
11q LOH
Monday 20 June 2005
Tumors
Wilms tumor (17099873, 16518847)
pulmonary carcinomas
colorectal adenocarcinomas (colorectal cancer)
mammary carcinomas (breast cancer) ( 60%)
cervical squamous cell carcinoma
head and neck squamous cell carcinoma (HNSCC) ( 60%)
ovarian carcinomas ( 60%)
Localization
11q22-q24 LOH
- pulmonary carcinomas
- colonic carcinomas
- mammary carcinomas
- cervical carcinomas
- head and neck carcinomas (17492757)
See also
11q loss (CGH)
11q deletion (Cytogenetics)
Oncobase
References
Parikh RA, White JS, Huang X, Schoppy DW, Baysal BE, Baskaran R, Bakkenist CJ, Saunders WS, Hsu LC, Romkes M, Gollin SM. Loss of distal 11q is associated with DNA repair deficiency and reduced sensitivity to ionizing radiation in head and neck squamous cell carcinoma. Genes Chromosomes Cancer. 2007 May 10;46(8):761-775 PMID: 17492757
Wittmann S, Zirn B, Alkassar M, Ambros P, Graf N, Gessler M. Loss of 11q and 16q in Wilms tumors is associated with anaplasia, tumor recurrence, and poor prognosis. Genes Chromosomes Cancer. 2007 Feb;46(2):163-70. PMID: 17099873
Watanabe N, Nakadate H, Haruta M, Sugawara W, Sasaki F, Tsunematsu Y, Kikuta A, Fukuzawa M, Okita H, Hata J, Soejima H, Kaneko Y. Association of 11q loss, trisomy 12, and possible 16q loss with loss of imprinting of insulin-like growth factor-II in Wilms tumor. Genes Chromosomes Cancer. 2006 Jun;45(6):592-601. PMID: 16518847