mammary carcinomas

 |BP|

Breast carcinomas with a worse prognosis than invasive ductal carcinomas include basal-like breast carcinoma , invasive micropapillary carcinoma , metaplastic carcinoma , and Her-2 + / HER2+ carcinomas.

Carcinomas with a better prognosis than invasive ductal carcinoma: secretory carcinoma , medullary carcinoma , tubular carcinoma , colloid carcinoma , and adenoid cystic carcinoma , pictured here.

Unlike the salivary gland, adenoid cystic carcinoma of the breast has a relatively good prognosis.

2012 WHO Classification of Tumors of the Breast

Epithelial tumors

Microinvasive carcinoma

Invasive breast carcinoma

 invasive ductal carcinoma

 Invasive carcinoma of no special type (NST)

• Pleomorphic carcinoma
• Carcinoma with osteoclast like stromal giant cells
• Carcinoma with choriocarcinomatous features
• Carcinoma with melanotic features

 Invasive lobular carcinoma

• Classic lobular carcinoma
• Solid lobular carcinoma
• Alveolar lobular carcinoma
• Pleomorphic lobular carcinoma
• Tubulolobular carcinoma
• Mixed lobular carcinoma

 Tubular carcinoma
 Cribiform carcinoma
 Mucinous carcinoma
 Carcinoma with medullary features

• Medullary carcinoma
• Atypical medullary carcinoma
• Invasive carcinoma NST with medullary features

 Carcinoma with apocrine differentiation
 Carcinoma with signet ring differentiation
 Invasive micropapillary carcinoma
 Metaplastic carcinoma of no special type

• Low-grade adenosquamous carcinoma
• Fibromatosis like metaplastic carcinoma
• Squamous cells carcinoma
• Spindle cell carcinoma
• Metaplastic carcinoma with mesenchymal differentiation
  • Chondroid differentiation
  • Osseous differentiation

• Other types of mesenchymal differentiation
• Mixed metaplastic carcinoma
• Myoepithelial carcinoma

 Rare types

• Carcinoma with neuroendocrine features
  • Neuroendocrine tumor, well differentiated
  • Neuroendocrine carcinoma, poorly differentiated (small cell carcinoma)
  • Carcinoma with neuroendocrine differentiation

• Secretory carcinoma
• Invasive papillary carcinoma
• Acinic cell carcinoma
• Mucoepidermoid carcinoma
• Polymorphous carcinoma
• Oncocytic carcinoma
• Lipid rich carcinoma
• Glycogen rich clear cell carcinoma
• Sebaceous carcinoma
• Salivary gland / skin adnexal type tumors
  • Cylindroma
  • Clear cell hidradenoma

Types - OMS 2003

http://www.pathologyoutlines.com/topic/breastmalignantwhoclassification.html

 mammary invasive ductal carcinoma
 mammary invasive lobular carcinoma
 mammary invasive tubular carcinoma
 mammary invasive cribriform carcinoma
 mammary medullary carcinoma
 mammary mucinous carcinoma
 mammary neuroendocrine carcinoma
 mammary invasive papillary carcinoma
 mammary invasive micropapillary carcinoma
 mammary apocrine carcinoma
 mammary metaplastic carcinomas
 mammary lipid-rich carcinoma
 mammary secretory carcinoma
 mammary oncocytic carcinoma
 mammary adenoid cystic carcinoma
 mammary acinic cell carcinoma
 mammary glycogen-rich clear cell carcinoma
 mammary sebaceous carcinoma
 mammary inflammatory
 mammary lobular neoplasia
 mammary intraductal proliferative lesions
 mammary microinvasive carcinoma
 mammary intraductal papillary tumors

Types according to tumoral invasion

 mammary invasive carcinomas
 mammary non-invasive carcinomas

Digital cases

 JRC:5418 : Breast lobular carcinoma in situ.
 JRC:5436 : Mammary invasive lobular carcinoma.
 JRC:4946 : Invasive ductal carcinoma of the breast.
 JRC:4055 : Mammary papillary carcinoma.
 JRC:4061 : Mammary papillary carcinoma.
 JRC:4938 : Apocrine carcinoma of the breast.
 JRC:5032 : Medullary carcinoma of the breast.
 JRC:5139 : Undifferentiated carcinoma of the breast.

Differential diagnosis

 mammary benign proliferative lesions (mammary benign epithelial proliferations )

Immunochemistry

Breast cancer risk

 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. (23535729)

Links

 http://www.breastpathology.info/Common%20cancers.html

 Breast carcinoma pathology

• http://www.slideshare.net/kirubavijay
• http://fr.slideshare.net/kirubavijay/breast-carcinoma-pathology

See also

 mammary tumors
 breast cancer

References

 Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Michailidou K, Hall P, Gonzalez-Neira A et al. Nat Genet. 2013 Apr;45(4):353-61, 361e1-2. doi : 10.1038/ng.2563 PMID: 23535729

 Special types of invasive breast cancer, with clinical implications. Page DL. Am J Surg Pathol. 2003 Jun;27(6):832-5. PMID: 12766589