mammary secretory carcinoma

Definition: Secretory carcinomas are distinguished from infiltrating ductal carcinomas of the breast by their characteristic histomorphology and more favorable prognosis and by the expression of a chimeric tyrosine kinase that is encoded by the ETV6-NTRK3 fusion gene.

Secretory carcinoma is the most common breast carcinoma in young persons, and is also called “juvenile carcinoma.” It is associated with t(12;15) and is usually triple negative. Microscopically, it shows a hyalinized stroma with tubuloalveolar or papillary growth.

It has a favorable prognosis, is negative for ER, PR and HER2, and is associated with t(12;15) ETV6-NTRK3 fusion gene.

Etiology

 ETV6-NTRK3 fusion gene by translocation t(12;15)(p13;q25)

See also

 secretory carcinoma

• salivary secretory carcinoma

References

 Secretory Breast Carcinoma: A Histopathologic and Genomic Spectrum Characterized by a Joint Specific ETV6-NTRK3 Gene Fusion. Del Castillo M, Chibon F, Arnould L, Croce S, Ribeiro A, Perot G, Hostein I, Geha S, Bozon C, Garnier A, Lae M, Vincent-Salomon A, MacGrogan G. Am J Surg Pathol. 2015 Nov;39(11):1458-67. doi : 10.1097/PAS.0000000000000487 PMID: 26291510

 Mammary Analogue Secretory Carcinoma of Salivary Glands, Containing the ETV6-NTRK3 Fusion Gene: A Hitherto Undescribed Salivary Gland Tumor Entity. Skálová A, Vanecek T, Sima R, Laco J, Weinreb I, Perez-Ordonez B, Starek I, Geierova M, Simpson RH, Passador-Santos F, Ryska A, Leivo I, Kinkor Z, Michal M. Am J Surg Pathol. 2010 Apr 20. PMID: 20410810

 Diallo R, Schaefer KL, Bankfalvi A, Decker T, Ruhnke M, Wulfing P, Jackisch C, Luttges J, Sorensen PH, Singh M, Poremba C. Secretory carcinoma of the breast: a distinct variant of invasive ductal carcinoma assessed by comparative genomic hybridization and immunohistochemistry. Hum Pathol. 2003 Dec;34(12):1299-305. PMID: 14691916