3p12 LOH

Homozygous deletions or loss of heterozygosity (LOH) at human chromosome band 3p12 are consistent features of lung and other malignancies, suggesting the presence of a tumor suppressor gene(s) (TSG) at this location.

Target genes

 ROBO1 (or DUTT1 (Deleted in U Twenty Twenty), FLJ21882, SAX3)

• ROBO1 (DUTT1), the human ortholog of the fly gene ROBO, has homology with NCAM proteins.
• Extensive analyses of ROBO1 in lung cancer have not revealed any mutations, suggesting that another gene(s) at this location could be of importance in lung cancer initiation and progression.

References

 Angeloni D, ter Elst A, Wei MH, van der Veen AY, Braga EA, Klimov EA, Timmer T, Korobeinikova L, Lerman MI, Buys CH. Analysis of a new homozygous deletion in the tumor suppressor region at 3p12.3 reveals two novel intronic noncoding RNA genes. Genes Chromosomes Cancer. 2006 Jul;45(7):676-91.PMID: 16607615