8p22-p23 LOH

Tumors

 prostatic adenocarcinoma (16470536)

• Allelic loss at 8p22-p23 was significantly more frequent in clinical prostate cancer (CPC) than in incidental prostate cancer and in pT4 CPC than in earlier-stage CPC. (16470536)
• Deletion of 8p is an important event in both the initiation and metastasis of prostate cancer.
• The extremely high frequency of LOH at 8p22-23.1 in high-grade tumors suggests the existence of a novel putative tumor-suppressor gene associated with the progression of prostate cancer.

References

 Lu W, Takahashi H, Furusato B, Maekawa S, Ikegami M, Sudo A, Egawa S, Hano H. Allelotyping analysis at chromosome arm 8p of high-grade prostatic intraepithelial neoplasia and incidental, latent, and clinical prostate cancers. Genes Chromosomes Cancer. 2006 May;45(5):509-15. PMID: 16470536