Tumoral translocations

• t(1;10)(p22;q24)
  16 January 2017

  Molecular Pathology
  t(1;10)(p22;q24) with gene fusion of TGFBR3 and MGEA5 in myxoinflammatory fibroblastic sarcoma and hemosiderotic fibrolipomatous tumor. (#21717526#)

• t(5;8)(p15;q13)
  13 January 2017

  Pathology
  RHOH-NCOA2 gene fusion involving RHOH ( AHRR ) and NCOA2 genes by t(5;8)(p15;q13) in soft tissue angiofibroma

• t(11,16)(p11;p11)
  28 December 2016

  Pathology
  Low-grade fibromyxoid sarcoma (LGFMS) bear either the t(7,16)(q32-34;p11) or t(11,16)(p11;p11) translocations, resulting in FUS-CREB3L2 or FUS-CREB3L1 fusions, respectively.

• t(7,16)(q32-34;p11)
  28 December 2016

  Pathology
  Low-grade fibromyxoid sarcoma (LGFMS) bear either the t(7,16)(q32-34;p11) or t(11,16)(p11;p11) translocations, resulting in FUS-CREB3L2 or FUS-CREB3L1 fusions, respectively.

• t(12;14)(p13;q32)
  25 May 2016

  AGCOH
  Pathology
  Detection of t(12;14)(p13;q32) in a patient with IGH-CCND1 negative mantle cell lymphoma resembling ultra-high risk chronic lymphocytic leukemia. (#26261659#)
  Open references
  Detection of t(12;14)(p13;q32) in a patient with IGH-CCND1 negative mantle cell lymphoma resembling ultra-high risk chronic lymphocytic leukemia. Miao Y, Wang R, Fan L, Qiu H, Wu Y, Chen Y, Xu W, Li J. Int J Clin Exp Pathol. 2015 Jun 1;8(6):7494-8. PMID: #26261659# (...)

• t(5;14)(q31;q32)
  8 March 2016

  IL3-IgH fusion
  Tumors
  B-lymphoblastic lymphoma
  — hypereosinophilia and acute endocarditis.
  — IL3 hypersecretion and hypereosinophilia.
  Images
  https://twitter.com/evemariecrane/status/679715283020451840
  Open references
  The t(5;14) chromosomal translocation in a case of acute lymphocytic leukemia joins the interleukin-3 gene to the immunoglobulin heavy chain gene. Grimaldi JC, Meeker TC. Blood. 1989 Jun;73(8):2081-5. PMID: (...)

• t(9;12)(p22;q14)
  1 March 2016

  Tumors
  myolipoma
  Myolipoma of soft tissue is an extremely rare benign tumor composed of mature adipose tissue and smooth muscle cells. It is found predominantly in women.
  Open References
  Fusion of the HMGA2 and C9orf92 genes in myolipoma with t(9;12)(p22;q14).
  Panagopoulos I, Gorunova L, Agostini A, Lobmaier I, Bjerkehagen B, Heim S.
  Diagn Pathol. 2016 Feb 9;11(1):22. doi: 10.1186/s13000-016-0472-8.
  PMID: #26857357# (...)

• t(6;7)(p25;q32)
  1 March 2016

  t(6;7)(p25.3;q32.3)
  Open references
  Discovery of recurrent t(6;7)(p25.3;q32.3) translocations in ALK-negative anaplastic large cell lymphomas by massively parallel genomic sequencing. Feldman AL, Dogan A, Smith DI, Law ME, Ansell SM, Johnson SH, Porcher JC, Ozsan N, Wieben ED, Eckloff BW, Vasmatzis G. Blood. 2011 Jan 20;117(3):915-9. doi: 10.1182/blood-2010-08-303305. PMID: #21030553# (...)

• t(9;14)(p13;q32)
  12 December 2012

  Reference
  t(9;14)(p13;q32) involving the PAX-5 gene: a unique subtype of 14q32 translocation in B cell non-Hodgkin’s lymphoma. Amakawa R, Ohno H, Fukuhara S. Int J Hematol. 1999 Feb;69(2):65-9. PMID: #10071452#

• t(1;3)(p36;q21)
  12 December 2012

  Pathology
  AML/MDS-associated t(1;3)(p36;q21) with Waldenström’s macroglobulinemia (#7630185#)
  Reference
  Waldenström’s macroglobulinemia with the AML/MDS-associated t(1;3)(p36;q21). Johansson B, Waldenström J, Hasselblom S, Mitelman F. Leukemia. 1995 Jul;9(7):1136-8. PMID: #7630185#

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