Tumoral translocations

• t(6;11)(p21;q13)
  26 June 2007

  t(6;11)(p21;q12)

• t(11;19)(q11;q13)
  26 June 2007

  t(11;19)(q11;q13.4)

• t(12;19)(p13;p13)
  26 June 2007

  Pathology
  TCF3 rearrangements in B-cell precursor acute lymphoblastic leukemia (#17311319#)
  References
  Barber KE, Harrison CJ, Broadfield ZJ, Stewart AR, Wright SL, Martineau M, Strefford JC, Moorman AV. Molecular cytogenetic characterization of TCF3 (E2A)/19p13.3 rearrangements in B-cell precursor acute lymphoblastic leukemia. Genes Chromosomes Cancer. 2007 May;46(5):478-86. PMID: (...)

• t(13;19)(q14;p13)
  26 June 2007

  Pathology
  TCF3 rearrangements in B-cell precursor acute lymphoblastic leukemia (#17311319#)
  References
  Barber KE, Harrison CJ, Broadfield ZJ, Stewart AR, Wright SL, Martineau M, Strefford JC, Moorman AV. Molecular cytogenetic characterization of TCF3 (E2A)/19p13.3 rearrangements in B-cell precursor acute lymphoblastic leukemia. Genes Chromosomes Cancer. 2007 May;46(5):478-86. PMID: (...)

• t(6;22)(p21;q12)
  18 June 2007

  The t(6;22)(p21;q12) translocation associated with human bone and soft-tissue tumors results in a chimeric molecule fusing the amino terminal domain (NTD) of the EWS gene to the carboxy terminal domain (CTD) of the Oct-4 embryonic gene (POU5F1). The fusion of the EWS amino terminal domain to the Oct-4 DNA binding domain produces a transforming chimeric product.
  References
  Lee J, Kim JY, Kang IY, Kim HK, Han YM, Kim J. The EWS-Oct-4 fusion gene encodes a transforming gene. Biochem J. 2007 (...)

• t(6;10)(q27;q11)
  29 May 2007

  Pathology
  idiopathic myelofibrosis
  eosinophilia
  References
  Cox MC, Panetta P, Venditti A, Abruzzese E, Del Poeta G, Cantonetti M, Amadori S. New reciprocal translocation t(6;10) (q27;q11) associated with idiopathic myelofibrosis and eosinophilia. Leuk Res. 2001 Apr;25(4):349-51. PMID: #11248333#

• t(1;14)(q12;p11)
  28 May 2007

  Tumors
  chronic myelomonocytic leukemia (CMML) myelodysplastic syndromes (MDS)
  References
  Djordjevic V, Jankovic G, Suvajdzic N, Marisavljevic D, Pantic M, Bogdanovic A, Sefer D, Dencic M, Colovic M. A der(14)t(1;14)(q12;p11) in chronic myelomonocytic leukemia. Cancer Genet Cytogenet. 2005 Jul 1;160(1):89-93. PMID: #15949578#

• t(3;21)(q26;q22)
  28 May 2007

  The t(3;21)(q26;q22) translocation is associated with myeloid leukemias and results in a chimeric oncoprotein containing AML1/RUNX1 variably fused to EAP, MDS1, and/or EVI1.
  Tumors
  acute myeloid leukemia (AML) post-chemotherapy acute myeloid leukemia (AML)
  chronic myeloproliferative disorders (CMPD) chronic myelogenous leukemia (CML) myeloid blast transformation
  see also
  t(3;21)-associated acute myeloid leukemia
  Molecular biology
  fusion transcripts between AML1 and EAP, MDS1, (...)

• t(2;3)(p15-22;q26)
  28 May 2007

  t(2;3)(p15-22;q26)

• t(1;2)(q21; p23)
  23 May 2007

  unknown gene-ALK
  Tumors
  inflammatory myofibroblastic tumor (IMT) (#16831032#)
  References
  Cole B, Zhou H, McAllister N, Afify Z, Coffin CM. Inflammatory myofibroblastic tumor with thrombocytosis and a unique chromosomal translocation With ALK rearrangement. Arch Pathol Lab Med. 2006 Jul;130(7):1042-5. PMID: #16831032#

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