Tumoral inversions

Inv(3)(q21q26)/t(3;3)(q21;q26.2) is the most common form of genetic abnormality of the so-called 3q21q26 syndrome.
Myeloid neoplasms with 3q21q26 aberrancies include acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), and blast crisis of myeloproliferative neoplasms.
Although the AML and MDS with inv(3)/t(3;3) are listed as a separate category of myeloid malignancies in the 2008 World Health Organization classification, the overlapping clinicopathologic features, similar overall (...)

Tumors
giant cell reparative grauloma (GCRG) (#17527082#)
References
Novel karyotypes in giant cell-rich lesions of bone. Gleason BC, Kleinman PK, Debelenko LV, Rahbar R, Gebhardt MC, Perez-Atayde AR. Am J Surg Pathol. 2007 Jun;31(6):926-32. PMID: #17527082#

The genome of a subset of non-small-cell lung cancers (NSCLC) harbors a small inversion within chromosome 2 that gives rise to a transforming fusion gene, EML4-ALK, which encodes an activated protein tyrosine kinase.
Although breakpoints within EML4 have been identified in introns 13 and 20, giving rise to variants 1 and 2, respectively, of EML4-ALK, it has remained unclear whether other isoforms of the fusion gene are present in NSCLC cells.
Shortcuts
EML4-ALK fusion is a rare acquired (...)

Tumors
metanephric adenoma (#15747102#)
See also
Oncobase

Tumors
extrarenal malignant rhabdoid tumor (#11004236#)
References
Staehelin F, Bissig H, Hösli I, Betts DR, Schäfer BW, Scholl FA, Holzgreve W, Kühne T. Inv(11)(p13p15) and myf-3(MyoD1) in a malignant extrarenal rhabdoid tumor of a premature newborn. Pediatr Res. 2000 Oct;48(4):463-7. PMID: #11004236#

Pathology
MLL/MAML2 gene fusion in secondary acute myelogenous leukemia (#17551948#) myelodysplastic syndrome with inv(11)(q21q23) (#17551948#)
References
Nemoto N, Suzukawa K, Shimizu S, Shinagawa A, Takei N, Taki T, Hayashi Y, Kojima H, Kawakami Y, Nagasawa T. Identification of a novel fusion gene MLL-MAML2 in secondary acute myelogenous leukemia and myelodysplastic syndrome with inv(11)(q21q23). Genes Chromosomes Cancer. 2007 Jun 5 ; PMID : (...)

Tumors
thyroid papillary carcimoma
See also
Oncobase tumoral inversions

inv(16)