Tumoral translocations

• t(9;15)(p24;q24)
  11 February 2008

  Tumors
  metanephric adenoma (#15747102#)

• t(8;16)(p11;p13)
  29 January 2008

  Molecular biology
  MOZ/CBP fusion gene
  MOZ at 8p11
  CBP at 16p13
  Tumors
  acute myeloid leukemia (AML)
  M4, M5a, M5b
  References
  The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein. Borrow J, Stanton VP Jr, Andresen JM, Becher R, Behm FG, Chaganti RS, Civin CI, Disteche C, Dube I, Frischauf AM, Horsman D, Mitelman F, Volinia S, Watmore AE, Housman DE. Nat Genet. 1996 Sep;14(1):33-41. Medline #96376968 #
  The (...)

• t(12;13)(p13;q12)
  29 January 2008

  The t(12;13)(p13;q12) is a rare, recurrent translocation reported in a range of hematological malignancies.
  Molecular biology
  ETV6/CDX2 fusion gene
  ETV6 at 12p13
  CDX2 at 13q12
  Tumors
  acute myeloid leukemia (#9920852#)
  atypical chronic myeloproliferative disorder (#7861615#)
  t(12;13)
  Translocations between the long arm of chromosome 13 and the short arm of chromosome 12 are rare nonrandom abnormalities in acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), (...)

• t(8;13)(q24;q33)
  25 January 2008

  t(8;13)(q24.2;q33)

• t(10;17)(q22;p13)
  21 December 2007

  Tumors
  clear cell sarcoma of kidney (CCSK) (#15474157#)
  endometrial stromal sarcoma (ESS) (#23599159#)
  YWHAE-FAM22 fusion gene in endometrial stromal sarcoma by t(10;17)(q22;p13)
  YWHAE rearrangement identified by FISH and RT-PCR in endometrial stromal sarcomas (#23599159#)
  Endometrial stromal sarcomas represent the second most common mesenchymal uterine tumor.
  The 2003 WHO classification distinguishes low-grade and undifferentiated endometrial stromal sarcomas with different (...)

• t(2;6)(q31;p21)
  10 December 2007

  t(2;6)(q31;p21.3)

• t(8;14)(q24;q32)
  4 December 2007

  The presence of the typical t(8;14)(q24;q32) or its variants has been confirmed in all cases of Burkitt lymphoma (BL), in some cases of Burkitt-like lymphoma (BLL), and in diffuse large B-cell lymphoma (DLBCL).
  The alterations lead to deregulated expression of c-myc protein by a chromosomal translocation joining C-MYC gene with sequences from immunoglobulin (Ig) enhancers.
  The C-MYC gene rearrangement plays an essential role in leukemogenesis of BL and probably plays a part in other (...)

• t(10;11)(p13-14;q14)
  28 November 2007

  t(10;11)(p13-14;q14-21)

• t(19;21)(p13;p13)
  28 November 2007

  Tumors
  t(9;22)(q34;q11) BCR/ABL-positive acute lymphoblastic leukemia in relapse (#18036399#)
  References
  Struski S, Hélias C, Gervais C, Leymarie V, Audhuy B, Moskovtchenko P, Lutz P, Gaub MP, Lessard M.Confirmation of a novel recurrent association: BCR-ABL t(9;22) and t(19;21).Cancer Genet Cytogenet. 2007 Dec;179(2):127-31. PMID: #18036399#

• t(1;15)(q10;q10)
  28 November 2007

  Tumors
  acute lymphoblastic leukemia (#18036400#)
  References
  Park TS, Song J, Lee KA, Lee SG, Yoon S, Kim JS, Lyu CJ, Choi JR.A der(1;15)(q10;q10) is a rare nonrandom whole-arm translocation in patients with acute lymphoblastic leukemia.Cancer Genet Cytogenet. 2007 Dec;179(2):132-5. PMID: #18036400#

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