Tumoral translocations

• t(8;10)(q21;q24)
  18 May 2007

  Tumors
  mesenchymoma (#15134997#)
  References
  Joniau S, Goeman L, Kreuzbauer S, Bogaert G, Dal Cin P, Oyen R, Sciot R, van Poppel H. Benign renal mesenchymoma in the pediatric age group: a novel pathologic and karyotype entity. Urology. 2004 May;63(5):981-4. PMID: #15134997#

• t(11;17)(q23;q12-q21)
  18 May 2007

  Tumors
  acute myelocytic leukemia (AML)
  Molecular biology
  fusion of MLL at 11q23 (MIM.159555) and MLLT6 (AF17) at 17q21 (MIM.600328)
  References
  Prasad, R.; Leshkowitz, D.; Gu, Y.; Alder, H.; Nakamura, T.; Saito, H.; Huebner, K.; Berger, R.; Croce, C. M.; Canaani, E. : Leucine-zipper dimerization motif encoded by the AF17 gene fused to ALL-1 (MLL) in acute leukemia. Proc. Nat. Acad. Sci. 91: 8107-8111, 1994. PubMed ID : (...)

• t(X;21)(q25-26;q22)
  17 May 2007

  Molecular biology
  ELF4/ERG fusion gene (#16303180#) ELF4 at Xq25-26 ERG at 21q22
  Tumors
  acute myeloid leukemia (#16303180#)
  References
  Moore SD, Offor O, Ferry JA, Amrein PC, Morton CC, Dal Cin P. ELF4 is fused to ERG in a case of acute myeloid leukemia with a t(X;21)(q25-26;q22). Leuk Res. 2006 Aug;30(8):1037-42. PMID: #16303180#

• t(2;16)(q35;p11)
  26 March 2007

  Pathology
  FUS/FEV fusion gene between FEV at 2q35 and FUS at 16p11
  Tumors
  Ewing sarcoma
  References
  Ng TL, O’Sullivan MJ, Pallen CJ, Hayes M, Clarkson PW, Winstanley M, Sorensen PH, Nielsen TO, Horsman DE. Ewing sarcoma with novel translocation t(2;16) producing an in-frame fusion of FUS and FEV.J Mol Diagn. 2007 Sep;9(4):459-63. PMID: #17620387#

• t(4;19)(q35;q13)
  1 February 2007

  t(4;19)(q35;q13.1):

• t(1;19)(q10;p10)
  31 January 2007

  Tumors
  oligodendroglioma (#17047046#)
  References
  Jenkins RB, Blair H, Ballman KV, Giannini C, Arusell RM, Law M, Flynn H, Passe S, Felten S, Brown PD, Shaw EG, Buckner JC. A t(1;19)(q10;p10) mediates the combined deletions of 1p and 19q and predicts a better prognosis of patients with oligodendroglioma. Cancer Res. 2006 Oct 15;66(20):9852-61. PMID: #17047046#

• t(8;12)(p11;q24)
  31 January 2007

  Tumors
  solitary fibrous tumor of the pleura (#17175385#)
  References
  Horton ES, Dobin SM, Donner LR. A clonal t(8;12)(p11.2;q24.3) as the sole abnormality in a solitary fibrous tumor of the pleura. Cancer Genet Cytogenet. 2007 Jan 1;172(1):77-9. PMID: #17175385#

• t(5;9)(q11;q34)
  26 January 2007

  Pathology
  constitutional balanced t(5;9)(q11;q34) in hypereosinophilia (#12415045#)
  See also
  chromosomal translocations
  References
  Horenstein MS, Humes R, Epstein ML, Draper D. Loffler’s endocarditis presenting in 2 children as fever with eosinophilia. Pediatrics. 2002 Nov;110(5):1014-8. PMID: #12415045#

• t(X;18)(p11;q11)
  23 January 2007

  t(X;18)(p11.2;q11.2)

• t(X;1)(p11;q21)
  23 January 2007

  Tumor
  TFE3-associated papillary renal cell carcinoma (juvenile papillary renal cell carcinoma)
  See also
  Oncobase tumoral translocations
  References
  Tonk V, Wilson KS, Timmons CF, Schneider NR, Tomlinson GE. Renal cell carcinoma with translocation (X;1). Further evidence for a cytogenetically defined subtype. Cancer Genet Cytogenet. 1995 May;81(1):72-5. PMID: #7773963#
  Tomlinson GE, Nisen PD, Timmons CF, Schneider NR. Cytogenetics of a renal cell carcinoma in a 17-month-old child. (...)

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