Home > G. Tumoral pathology > Molecular pathology of tumors > Genetic anomalies > Cancer cytogenetics > Tumoral translocations > t(X;18)(p11;q11)
t(X;18)(p11;q11)
Tuesday 23 January 2007
A t(X;18)(p11.2;q11.2) is found in almost all synovial sarcomas (8O%).
The translocation t(X ;18)(p11.2 ;q11.2) seems to be specific : it is not found in other spindle cell sarcomas, and very rarely detected in other tumors as malignant fibrous histyocytoma (MFH) or fibrosarcomas.
Molecular biology
SYT at 18q11.2 and SSX1, SSX2, SSX4 at Xp11.2
- SYT/SSX1 fusion gene
- SYT/SSX2 fusion gene
- SYT/SSX4 fusion gene
Tumors
synovial sarcoma
See also
Oncobase
- tumoral translocations
References
Translocations involving the X chromosome in solid tumors : presentation of two sarcomas with t(X ;18)(q13,p11). Limon J, Dal Cin P, Sandberg AA. Cancer Genet Cytogenet 1986; 23: 87-91.