Home > G. Tumoral pathology > Molecular pathology of tumors > Genetic anomalies > Cancer cytogenetics > Tumoral translocations > t(8;16)(p11;p13)
t(8;16)(p11;p13)
Tuesday 29 January 2008
Molecular biology
MOZ/CBP fusion gene
- MOZ at 8p11
- CBP at 16p13
Tumors
acute myeloid leukemia (AML)
- M4, M5a, M5b
References
The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein. Borrow J, Stanton VP Jr, Andresen JM, Becher R, Behm FG, Chaganti RS, Civin CI, Disteche C, Dube I, Frischauf AM, Horsman D, Mitelman F, Volinia S, Watmore AE, Housman DE. Nat Genet. 1996 Sep;14(1):33-41. Medline #96376968 #
The 8p11 anomaly in "monoblastic" leukaemia. Brizard A, Guilhot F, Huret JL, Benz-Lemoine E, Tanzer J. Leuk Res. 1988;12(8):693-7. Medline 89038614
Therapy-related acute myeloid leukemia with t(8;21), inv(16), and t(8;16): a report on 25 cases and review of the literature. Quesnel B, Kantarjian H, Bjergaard JP, Brault P, Estey E, Lai JL, Tilly H, Stoppa AM, Archimbaud E, Harousseau JL, et al J Clin Oncol. 1993 Dec;11(12):2370-9. Medline 94065868
A distinct subtype of M4/M5 acute myeloblastic leukemia (AML) associated with t(8:16)(p11:p13), in a patient with the variant t(8:19)(p11:q13)—case report and review of the literature. Stark B, Resnitzky P, Jeison M, Luria D, Blau O, Avigad S, Shaft D, Kodman Y, Gobuzov R, Ash S, et al. Leuk Res. 1995 Jun;19(6):367-79. Medline 95319179
Translocation t(8;16)(p11;p13) in acute non-lymphocytic leukemia: report on two new cases and review of the literature. Velloso ER, Mecucci C, Michaux L, Van Orshoven A, Stul M, Boogaerts M, Bosly A, Cassiman JJ, Van Den Berghe H. Leuk Lymphoma. 1996 Mar;21(1-2):137-42. Medline 97063414