t(3;21)(q26;q22)
The t(3;21)(q26;q22) translocation is associated with myeloid leukemias and results in a chimeric oncoprotein containing AML1/RUNX1 variably fused to EAP, MDS1, and/or EVI1.
acute myeloid leukemia (AML)
- post-chemotherapy acute myeloid leukemia (AML)
chronic myeloproliferative disorders (CMPD)
- chronic myelogenous leukemia (CML)
- myeloid blast transformation
see also
t(3;21)-associated acute myeloid leukemia
Molecular biology
fusion transcripts between AML1 and EAP, MDS1, or EVI1
References
Yin CC, Cortes J, Barkoh B, Hayes K, Kantarjian H, Jones D. t(3;21)(q26;q22) in myeloid leukemia: an aggressive syndrome of blast transformation associated with hydroxyurea or antimetabolite therapy. Cancer. 2006 Apr 15;106(8):1730-8. PMID: 16532439