NRAS

Pathology

 somatic mutations in

• colorectal adenocarcinomas (colonic carcinoma)
• thyroid follicular carcinoma
• rhabdomyosarcomas (18.2%) (16518851)

 NRAS mutations are rare in colorectal cancer. (20736745)

• NRAS mutations are detected in 2.2% of colorectal cancers (20736745)

Main mutations

 NRAS-Q61R

See also

 RASs

References

 NRAS mutations are rare in colorectal cancer. Irahara N, Baba Y, Nosho K, Shima K, Yan L, Dias-Santagata D, Iafrate AJ, Fuchs CS, Haigis KM, Ogino S. Diagn Mol Pathol. 2010 Sep;19(3):157-63. PMID: 20736745

 Chen Y, Takita J, Hiwatari M, Igarashi T, Hanada R, Kikuchi A, Hongo T, Taki T, Ogasawara M, Shimada A, Hayashi Y. Mutations of the PTPN11 and RAS genes in rhabdomyosarcoma and pediatric hematological malignancies. Genes Chromosomes Cancer. 2006 Jun;45(6):583-91. PMID: 16518851