ADAR2

Pathology

 Metabolomic and Lipidomic Profiling Identifies The Role of the RNA Editing Pathway in Endometrial Carcinogenesis.

• ADAR2 is overexpressed in EC and that the increase in expression positively correlates with the aggressiveness of the tumor.
• Furthermore, silencing of ADAR2 in three EC cell lines resulted in a decreased proliferation rate, increased apoptosis, and reduced migration capabilities in vitro.
• ADAR2 functions as an oncogene in endometrial carcinogenesis and could be a potential target for improving EC treatment strategies.
• doi : 10.1038/s41598-017-09169-2

See also

 ADARs
 RNA editing