Metabolome

• cyclopamine
  20 December 2012

  WKP
  Cyclopamine (11-deoxojervine) is a naturally occurring chemical that belongs to the group of steroidal jerveratrum alkaloids.
  SHH pathway inhibition
  Cyclopamine inhibits the hedgehog signaling pathway (Hh) by influencing the balance between the active and inactive forms of the smoothened protein.
  Cyclopamine can prevent the fetal brain from dividing into two lobes (holoprosencephaly) and cause the development of a single eye (cyclopia). It does so by inhibiting the hedgehog (...)

• phosphatidylserine
  4 January 2012

  Phosphatidylserine (abbreviated Ptd-L-Ser or PS) is a phospholipid component, usually kept on the inner-leaflet (the cytosolic side) of cell membranes by an enzyme called flippase.
  When a cell undergoes apoptosis, phosphatidylserine is no longer restricted to the cytosolic part of the membrane, but becomes exposed on the surface of the cell.
  See also
  phospholipids

• phosphatidylethanolamine
  4 January 2012

  cephalin
  Phosphatidylethanolamine (cephalin, sometimes abbreviated PE) is a lipid found in biological membranes. It is synthesized by the addition of CDP-ethanolamine to diglyceride, releasing CMP.
  S-adenosyl methionine can subsequently methylate the amine of phosphatidyl ethanolamine to yield phosphatidyl choline.
  Cephalin is a phospholipid, which is a lipid derivative. It is not to be confused with the molecule of the same name that is an alkaloid constituent of Ipecac.
  Structure
  In (...)

• phosphatidic acid
  4 January 2012

  Definition: Phosphatidic acids (PAs) are the acid forms of phosphatidates, a part of common phospholipids, major constituents of cell membranes.
  Phosphatidic acids are the simplest diacyl-glycerophospholipids.
  Structure
  Phosphatidic acid consists of a glycerol backbone, with, in general, a saturated fatty acid bonded to carbon-1, an unsaturated fatty acid bonded to carbon-2, and a phosphate group bonded to carbon-3.
  Formation and degradation
  Besides de novo synthesis, PA can be formed (...)

• phosphatidylcholine
  4 January 2012

  Definition: Phosphatidylcholines (PC) are a class of phospholipids that incorporate choline as a headgroup. They are a major component of biological membranes.
  Structure
  The phospholipid is composed of a choline head group and glycerophosphoric acid with a variety of fatty acids, one being a saturated fatty acid (in the example, here palmitic or hexadecanoic acid, H3C-(CH2)14-COOH; margaric acid identified by Gobley in egg yolk, or heptadecanoic acid H3C-(CH2)15-COOH, also belong to that (...)

• metabolomics
  25 November 2011

  Wikipedia
  Metabolomics is the scientific study of chemical processes involving metabolites. Specifically, metabolomics is the "systematic study of the unique chemical fingerprints that specific cellular processes leave behind", the study of their small-molecule metabolite profiles.
  The metabolome represents the collection of all metabolites in a biological cell, tissue, organ or organism, which are the end products of cellular processes.
  Thus, while mRNA gene expression data and (...)

• farnesyl pyrophosphate
  21 May 2009

  Definition: Farnesyl pyrophosphate (FPP) is an intermediate in the HMG-CoA reductase pathway used by organisms in the biosynthesis of terpenes and terpenoids (isoprenoids).
  It is the immediate precursor of squalene (via the enzyme squalene synthase), dehydrodolichol diphosphate (a precursor of dolichol), and geranylgeranyl pyrophoshate (GGPP).
  Farnesyl pyrophosphate (FPP), also known as farnesyl diphosphate (FDP), is an intermediate in the HMG-CoA reductase pathway used by organisms in (...)

• triterpene
  21 May 2009

  Triterpenes

• metabolite
  20 May 2009

  metabolites

• lanosterol
  21 July 2008

  Definition: Lanosterol is a tetracyclic triterpenoid, which is the compound from which all steroids are derived.
  Elaboration of lanosterol under enzyme catalysis leads to the core structure of steroids (lanosterol synthesis pathway).
  14-Demethylation of lanosterol by CYP51 eventually yields cholesterol.
  Biosynthesis
  Two molecules of farnesyl pyrophosphate (FPP) condense with reduction by NADPH to form squalene.
  Squalene is oxidized to 2,3-oxidosqualene (squalene epoxide). (...)

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