IHC markers

• CK19
  18 March

  PO
  See also : KRT19
  Diagnostic use :
  In Thyroid: confirm diagnosis of papillary thyroid carcinoma in cytology or equivocal cases (Arch Pathol Lab Med 2003;127:579, Mod Pathol 2006;19:1631); help distinguish follicular variant of papillary thyroid carcinoma (CK19+) from : (a) follicular adenoma (CK19-, Endocr Pathol 2006;17:213, Am J Clin Pathol 2006;126:700 but see Am J Clin Pathol 2001;116:696), (b) hyalinizing trabecular adenoma (CK19-, Am J Surg Pathol 2006;30:1269), (c) (...)

• NKX3.1
  14 March

  See NKX3A

• PRAME
  8 March

  Preferentially Expressed Antigen in Melanoma (PRAME) PO
  Definition : Preferentially expressed antigen in melanoma (PRAME) is a tumor-associated repressor of retinoic acid signaling which is expressed in melanoma and has emerged as a potential biomarker for malignant behavior in melanocytic neoplasms.
  PRAME protein expression in normal tissues is congruent with original molecular data being present in the testis, and at low levels in the endometrium, adrenal cortex, and adult as well (...)

• arginase
  2 August 2021

  Arginase-1 PO
  Positive staining - normal
  Hepatocytes
  Positive staining - diseases
  Cholangiocarcinoma, hepatocellular carcinoma
  Granuloma-associated macrophages; lung: type II pneumocytes (FEMS Immunol Med Microbiol 2012;66:265)
  Pancreatic adenocarcinoma (13%, Cancer Cytopathol 2012;120:230)
  Diagnostic use :
  hepatocellular carcinoma

• glypican-3
  2 August 2021

  PO
  See also : GPC3

• glutamine synthetase
  2 August 2021

  GLUL WKP PO
  Definition : Glutamine synthetase (GS) (EC 6.3.1.2)[3] is an enzyme that plays an essential role in the metabolism of nitrogen by catalyzing the condensation of glutamate and ammonia to form glutamine:
  Glutamate + ATP + NH3 → Glutamine + ADP + phosphate
  Diagnostic use
  hepatocellular carcinoma (HCC)
  See also
  IHC markers

• HSP70
  2 August 2021

  |WKP|PO|
  Diagnostic use
  hepatocellular carcinoma (HCC)
  See also
  IHC markers
  HSPs

• CEA
  23 October 2020

  polyclonal CEA

• Hep Par 1
  23 October 2020
• p63+
  13 October 2020

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