Home > A. Molecular pathology > NADPH
NADPH
Tuesday 8 August 2017
| WKP |
See also : NADH
Definition: Nicotinamide adenine dinucleotide phosphate, abbreviated NADP+ or, in older notation, TPN (triphosphopyridine nucleotide), is a cofactor used in anabolic reactions, such as lipid and nucleic acid synthesis, which require NADPH as a reducing agent.
NADPH is the reduced form of NADP+. NADP+ differs from NAD+ in the presence of an additional phosphate group on the 2’ position of the ribose ring that carries the adenine moiety.
The major source of NADPH in animals and other non-photosynthetic organisms is the pentose phosphate pathway.