Blood and immunity

• T-cell lymphoproliferation
  27 January 2010

  See also
  lymphoproliferation
  lymphropoliferative diseases

• B-cell lymphoproliferation
  27 January 2010

  B-cell lymphoproliferative diseases

• B-cell lymphoid hyperplasia
  27 January 2010

  See also
  lymphoid hyperplasias T-cell lymphoid hyperplasia

• T-cell lymphoid hyperplasia
  27 January 2010

  See also
  lymphoid hyperplasias

• plasmocytic Castleman disease
  6 January 2010

  plasma cell type of Castleman disease; plasma cell variant
  Digital case
  HPC:335 : Plasmocytic Castleman disease (associated to Kaposi sarcoma)
  Images
  https://twitter.com/KyleBradleyMD/status/732318591555645440
  Synopsis
  diffuse plasma cell proliferation in interfollicular tissue
  follicular hyperplasia without vascular hyaline changes
  interfollicular region showing a massive infiltration by plasma cells. Some of these plasma cells show multinucleation and mild nuclear atypia. (...)

• multicentric form of Castleman disease
  6 January 2010

  Synopsis
  Nearly always plasma cell type Castleman disease
  Presents with generalized lymphadenopathy
  May involve spleen
  Clinical and laboratory features similar to those of angioimmunoblastic lymphadenopathy
  May be associated with:
  POEMS syndrome: polyneuropathy, organomegaly, endocrinopathy, M-protein, skin changes
  include distinctive vascular lesion ‘glomeruloid hemangioma’
  amyloid deposits
  Kaposi sarcoma
  large cell lymphoma of immunoblastic type
  Tends to persist months (...)

• solitary form of Castleman disease
  6 January 2010

  Synopsis
  Presents as a mass: most common in mediastinum also described in: neck, lung, axilla, mesentery, broad ligament, retroperitoneum, soft tissues of extremities, nasopharynx, meninges, several other sites
  morphological types >90% are hyaline-vascular type Castleman disease: usually asymptomatic ≈10% plasma cell type Castleman disease: often associated with: fever, anemia, elevated erythrosedimentation rate, hypergammaglobulinemia, hypoalbuminemia
  Sometimes microscopic changes (...)

• hyaline vascular type-Castleman disease
  5 January 2010

  Images
  hyalin vascular Castleman disease vs follicular lymphoma
  https://twitter.com/KyleBradleyMD/status/751426265165533184
  Morphological synopsis
  Large follicles, scattered in mass of lymphoid tissue
  marked vascular proliferation
  hyalinization of abnormal germinal centers
  prominent germinal center showing well-developed vascular hyaline changes
  regressively transformed germinal centers
  many large cells with vesicular nuclei in hyaline center are follicular dendritic cells (...)

• intrapeithelial lymphocyte
  4 January 2010

  intrapeithelial lymphocytes, IEL

• blastic plasmacytoid dendritic cell neoplasm
  16 December 2009

  BPDCN

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