Environmental and occupational diseases

• environmental pollutants
  6 January

  Open references
  Environmental pollutants and the epidemiology of cancer.
  Heath CW Jr.
  Environ Health Perspect. 1978 Dec;27:7-10. doi:10.1289/ehp.78277.
  PMID: #83937# Free PMC article.

• glyphosate
  29 December 2018

  WKP
  Definition : Glyphosate (IUPAC name: N-(phosphonomethyl)glycine) is a broad-spectrum systemic herbicide and crop desiccant.
  It is an organophosphorus compound, specifically a phosphonate, which acts by inhibiting the plant enzyme 5-enolpyruvylshikimate-3-phosphate synthase.
  It is used to kill weeds, especially annual broadleaf weeds and grasses that compete with crops. It was discovered to be an herbicide by Monsanto chemist John E. Franz in (...)

• chlordecone
  29 December 2018

  kepone WKP
  Definition : Chlordecone (CD; Kepone™) is a carcinogenic organochlorine insecticide with neurological, reproductive, and developmental toxicity that was widely used in the French West Indies (FWI) from 1973 to 1993 to fight banana weevils.
  Chlordecone is an organochlorine compound and a colourless solid.
  This compound is an obsolete insecticide related to Mirex and DDT. Its use was so disastrous that it is now prohibited in the western world, but only after many millions (...)

• occupational diseases
  29 December 2018

  Occupational disease WKP
  Definition : An occupational disease is any chronic ailment that occurs as a result of work or occupational activity. It is an aspect of occupational safety and health.
  An occupational disease is typically identified when it is shown that it is more prevalent in a given body of workers than in the general population, or in other worker populations.
  The first such disease to be recognised, squamous-cell carcinoma of the scrotum, was identified in chimney (...)

• environmental diseases
  29 December 2018

  WKP
  Definition : In epidemiology, environmental diseases are diseases that can be directly attributed to environmental factors (as distinct from genetic factors or infection).
  Apart from the true monogenic genetic disorders, environmental diseases may determine the development of disease in those genetically predisposed to a particular condition.
  Stress, physical abuse and mental abuse , diet , exposure to toxins , pathogens , radiations , and chemicals found in almost all personal (...)

• environment
  29 December 2018

  WKP
  Definition : The natural environment encompasses all living and non-living things occurring naturally, meaning in this case not artificial. The term is most often applied to the Earth or some parts of Earth. This environment encompasses the interaction of all living species, climate, weather and natural resources that affect human survival and economic activity.
  Pathology
  environmental (...)

• smoking-associated cancers
  13 April 2016

  smoking-associated tumors; smoking-associated cancer
  It is estimated that cigarette smoking kills over 1 000 000 people each year by causing lung cancer as well as many other neoplasmas.
  p53 mutations are frequent in tobacco-related cancers and the mutation load is often higher in cancers from smokers than from nonsmokers.
  In lung cancers, the p53 mutational patterns are different between smokers and nonsmokers with an excess of G to T transversions in smoking-associated cancers.
  The (...)

• cellular response to UVB radiation
  10 April 2016

  References
  In vitro investigations on the effect of dermal fibroblasts on keratinocyte responses to ultraviolet B radiation. Fernandez TL, Van Lonkhuyzen DR, Dawson RA, Kimlin MG, Upton Z. Photochem Photobiol. 2014 Nov-Dec;90(6):1332-9. doi:10.1111/php.12317 . PMID: #25039640#

• References Ultraviolet damage, DNA repair...
  10 April 2016

  References
  Ultraviolet damage, DNA repair and vitamin D in nonmelanoma skin cancer and in malignant melanoma: an update. Reichrath J, Rass K. Adv Exp Med Biol. 2014;810:208-33. PMID: #25207368#

• DNA photoproducts
  10 April 2016

  Open references
  Photochemistry. Chemiexcitation of melanin derivatives induces DNA photoproducts long after UV exposure. Premi S, Wallisch S, Mano CM, Weiner AB, Bacchiocchi A, Wakamatsu K, Bechara EJ, Halaban R, Douki T, Brash DE. Science. 2015 Feb 20;347(6224):842-7. doi:10.1126/science.1256022 . PMID: #25700512# (Free)

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