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plasmocytic Castleman disease
Wednesday 6 January 2010
plasma cell type of Castleman disease; plasma cell variant
Digital case
HPC:335 : Plasmocytic Castleman disease (associated to Kaposi sarcoma)
Images
https://twitter.com/KyleBradleyMD/status/732318591555645440
Synopsis
diffuse plasma cell proliferation in interfollicular tissue
follicular hyperplasia without vascular hyaline changes
interfollicular region showing a massive infiltration by plasma cells. Some of these plasma cells show multinucleation and mild nuclear atypia.
Sometimes numerous Russell bodies
Hyaline-vascular changes in follicles inconspicuous or absent
Often deposition of an amorphous acidophilic material that probably contains fibrin and immune complexes in center of follicles
Overall appearance reminiscent of that in lymph nodes in rheumatoid arthritis
Association
HHV8-associated Kaposi sarcoma
Physiopathology
Abundant expression of interleukin-6: thought to be responsible for plasma cell infiltration.
Differential diagnosis
Idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia:
Oriental disease closely related to plasma cell type, but apparently not identical.
See also
Castleman disease
References
Multicentric Castleman disease in an HHV-8-infected child born to consanguineous parents. Leroy S, Moshous D, Cassar O, Reguerre Y, Byun M, Pedergnana V, Canioni D, Gessain A, Oksenhendler E, Fieschi C, Mahlaoui N, Rivière JP, Herbigneaux RM, Muszlak M, Arnaud JP, Fischer A, Picard C, Blanche S, Plancoulaine S, Casanova JL. Pediatrics. 2012 Jan;129(1):e199-203. PMID: 22157133