Blood and immunity

• therapy-related acute myeloid leukemia
  29 August 2008

  References
  Pedersen-Bjergaard J, Andersen MT, Andersen MK. Genetic pathways in the pathogenesis of therapy-related myelodysplasia and acute myeloid leukemia. Hematology Am Soc Hematol Educ Program 2007;2007:392-397. PMID: #18024656#

• therapy-related myelodysplasia
  29 August 2008

  References
  Pedersen-Bjergaard J, Andersen MT, Andersen MK. Genetic pathways in the pathogenesis of therapy-related myelodysplasia and acute myeloid leukemia. Hematology Am Soc Hematol Educ Program 2007;2007:392-397. PMID: #18024656#

• hematopoietic development
  25 June 2008

  The first hematopoietic and endothelial precursors arise from extra-embryonic mesoderm and differentiate to form the blood islands in the yolk sac of the early embryo.
  The close spatial and temporal development of these lineages within the blood islands provided the basis for the hypothesis that they arise from a common progenitor, the hemangioblast.
  Indirect evidence supporting the hemangioblast concept came from studies demonstrating that a large number of genes are expressed by both (...)

• regulatory dendritic cells
  20 April 2008

  regulatory DCs

• gamma/delta T lymphocytes
  15 January 2008

  gamma/delta T cells

• DC-SIGN(+)-dendritic cells
  8 January 2008

  HIV-1 infection
  Dendritic cells (DCs) are thought to mediate HIV-1 transmission but it is becoming evident that different DC subsets at the sites of infection have distinct roles.
  In the genital tissues, two different DC subsets are present: the Langerhans cells (LCs) and the DC-SIGN(+)-DCs.
  Although DC-SIGN(+)-DCs mediate HIV-1 transmission, recent data demonstrate that LCs prevent HIV-1 transmission by clearing invading HIV-1 particles.
  However, this protective function of LCs is (...)

• NK cells
  29 November 2007

  Natural killer (NK) cells express cell surface receptors that recognize major histocompatibility complex class I peptides (MIM.142800) and inhibit NK cell-mediated cytotoxicity.
  NK cell receptors belong to 2 distinct groups: the immunoglobulin superfamily for the killer cell inhibitory receptors (KIRs) (MIM.602992), and the C-type lectin superfamily for the NKG2 receptors (MIM.161555).
  These inhibitory receptors possess ’immunoreceptor tyrosine-based inhibitory motifs’ (ITIMs) in their (...)

• therapy-related acute lymphoblastic leukemia
  28 November 2007

  A highly increased risk of myelodysplasia (MDS) and acute myeloid leukaemia (AML) is well established in patients previously treated for other malignancies with alkylating agents or topoisomerase II inhibitors. Single cases of acute lymphoblastic leukaemia (ALL), often presenting balanced translocations involving chromosome band 11q23, have been observed.
  Cytogenetics
  11q23 rearrangements t(4;11)(q21;q23) (#11552977#)
  Molecular biology
  MLL fusion genes
  References
  Andersen MK, (...)

• early PTLD
  25 October 2007

  Types
  plasmacytic hyperplasia PTLD and plasma cell-rich PTLD (#11860313#)
  IMN-like PTLD (infectious mononucleosis-like PTLD)
  See also
  PTLDs

• monomorphic PTLD
  24 October 2007

  Monomorphic PTLD includes high-grade invasive lymphoma of B- or T-cells.
  This type of PTLD is often seen several years after transplantation and resembles non-Hodgkin’s lymphoma (NHL) as seen in the general population.
  Monomorphic B cell PTLD can be further divided into diffuse large cell lymphomas and Burkitt’s or Burkitt’s like lymphomas that display characteristic chromosomal translocations.
  Monomorphic T cell PTLD can be further divided according to whether it is large cell, anaplastic (...)

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