Blood and immunity

• post-transplantation lymphoproliferative disease
  5 September 2009

  posttransplantation lymphoproliferative disorders; post-transplantation lymphoproliferative syndrome

• c-kit-negative systemic mastocytosis
  17 June 2009

  References
  Complex karyotype and absence of mutation in the c-kit receptor in aggressive mastocytosis presenting with pelvic osteolysis, eosinophilia and brain damage. Jost E, Michaux L, Vanden Abeele M, Boland B, Latinne D, Godfraind C, Scheiff JM, Vaerman JL, Lecouvet F, Ferrant A. Ann Hematol. 2001 May;80(5):302-7. PMID: #11446735#

• neutrophil oxidative function
  15 June 2009

  Neutrophil oxidative function is now most easily tested by flow cytometry using dihydrorhodamine reduction.
  This test is quantitative and reasonably robust. It is more sensitive than the slide NBT (nitroblue tetrazolium) reduction test.
  While the latter can be readily performed, it may give false positive results (it may miss defects of neutrophil oxidative metabolism).
  The flow cytometric test is also valuable for identifying carriers with dual populations and can detect the low levels (...)

• FIP1L1/PDGFRA-associated chronic eosinophilic leukemia
  1 June 2009

  Cytogenetics
  FIP1L1-PDGFRA gene fusion by del(4)(q22q22) (#17377585#)
  Molecular biology
  The fusion protein PDGFRA/FIP1L1 between the platelet-derived growth factor receptor alpha (PDGFRA) gene and the Fip1-like1 (FIP1L1).
  References
  Systemic mastocytosis (SM) associated with chronic eosinophilic leukemia (SM-CEL): detection of FIP1L1/PDGFRalpha, classification by WHO criteria, and response to therapy with imatinib. Florian S, Esterbauer H, Binder T, Müllauer L, Haas OA, Sperr WR, (...)

• t(8;21)-associated acute myeloid leukemia
  1 June 2009

  t(8;21) acute myeloid leukemia, t(8;21)(q22;q22)-associated acute myeloid leukemia

• AML1/ETO acute myeloid leukemia
  1 June 2009

  AML1/ETO-positive acute myeloid leukemia, AML1/ETO-associated acute myeloid leukemia

• B- and T-cell antigens coexpressing lymphomas
  8 May 2009

  lymphoid neoplasms coexpressing B- and T-cell antigens

• T-cell and B-cell PTLDs association
  28 October 2008

  Posttransplant lymphoproliferative disorders (PTLDs) may occur as a complication of immunosuppression in patients who have received solid organ or bone marrow allografts.
  Most PTLDs are of B-cell lineage, whereas T-cell proliferations are rare.
  The majority of B-cell lesions are associated with Epstein-Barr virus infection.
  References
  Metachronous EBV-associated B-cell and T-cell posttransplant lymphoproliferative disorders in a heart transplant recipient. Morovic A, Jaffe ES, Raffeld (...)

• erythroid-predominant myelodysplastic syndrome
  15 October 2008

  In erythroid-predominant myelodysplastic syndrome, blast calculation as a proportion of marrow nonerythroid rather than total nucleated cells can better stratify patients into prognostically relevant groups. (#18839018#)
  Nota bene: In the FAB (French-American-British) and WHO (World Heath Organization) classifications, the blasts in erythroleukemia (M6a) are enumerated from the marrow nonerythroid rather than the total-nucleated cells. However, the method for blast calculation in (...)

• Shwachman-Diamond disease
  3 September 2008

  Shwachman-Diamond syndrome, Shwachman syndrome, Shwachman disease

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