trisomy 8
Trisomy 8 as the sole chromosomal aberration
hematological proliferations
- myelodysplastic syndromes (10%) (#17252907#, #16697122#)
- chronic lymphocytic leukemia (#17175382#, #18474297#)
- idiopathic myelofibrosis (#11248333#)
- myeloid sarcoma (#17974004#, #12437650#, #11697634#)
- acute myeloid leukemias (AML) (5%) (#16814381#, #16697122#)
- acute monocytic leukemia (FAB M5b) with trisomy 8
extraskeletal mesenchymal chondrosarcoma (#15899388#)
epithelioid smooth muscle tumor (#1868039#)
pediatric undifferentiated soft tissue sarcomas (USTS) (#17350464#)
chondroid cystic malformation of the lung with trisomy 8 mosaicism (#18520437#)
ovarian Sertoli-Leydig cell tumor (#11381376#)
NB: Trisomy 8 in acute myeloid leukemia (AML). Trisomy 8 is the most frequently observed trisomy in acute myeloid leukemia (AML) occurring as a sole karyotype abnormality or in addition to other chromosome aberrations. Trisomy 8 in AML determines no specific disease characteristic but is a disease modulating secondary event.
Trisomy 8 with associated anomalies
chronic myeloproliferative diseases (myeloid tumors) (but not found in essential thrombocythemia)
- chronic myelogenous leukemia (CML)
- polycytemia vera (PV)
- idiopathic myelofibrosis
myelodysplastic syndromes (MDS)
- refractory anemia (RA)
- refractory anemia with ring sideroblasts (RARS)
- refractory anemia with excess of blasts ± in transformation (RAEB±T)
- chronic myelomonocytic leukemia (CMML)
acute leukemias
- acute lymphocytic leukemia (ALL)
- acute myeloid leukemias (AML)
- acute monocytic leukemia (FAB M5b) with trisomy 8
non-Hodgkin Lymphomas
- Burkitt lymphoma
chronic lymphocytic leukemia (#17175382#, #17074592#, #18474297#)
- chronic lymphocytic leukemia with isolated trisomy 8 (#17175382#, #18474297#)
chronic lymphoproliferative diseases
- T-prolymphocytic leukaemia (exceptional)
embryonal tumors
- hepatoblastoma (#15981236#, #12228913#, #11996790#, #11943350#, #10696121#, #10526534#)
- embryonal rhabdomyosarcoma (#9973939#)
- esthesioneuroblastoma (#17321323#, #10574242#, #1756479#)
- pleuropulmonary blastoma (#17163790#, #9050063#, #11910518#, #10890933#, #12660036#)
soft tissue sarcomas
- Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET) (#11890993#, #11408064#, #9428352#, #9166930#, #8830730#)
- synovial sarcoma (#15325093#)
- leiomyosarcomas (#1796968#, #2246776#)
- extraskeletal mesenchymal chondrosarcoma (#15899388#)
- clear cell sarcoma of tendons and aponeuroses (#7685631#)
- alveolar soft part sarcoma (#11253120#, #7773967#)
- pediatric undifferentiated soft tissue sarcomas (USTS) (#17350464#)
- myxoid liposarcoma (#1993305#)
mammary carcinomas
See also
Oncobase
- tumoral trisomies
References
Bouron-Dal Soglio D, Rougemont AL, De Buys Roessingh AS, Fetni R, Rypens F, Bouchard S, Montpetit A, Fournet JC. Chondroid cystic malformation of the lung with trisomy 8 mosaicism: a new cystic lung malformation. Am J Surg Pathol. 2008 Jul;32(7):1095-100. PMID: #18520437#
Pozdnyakova O, Stachurski D, Hutchinson L, Ramakrishnan S, Miron PM. Trisomy 8 in B-cell chronic lymphocytic leukemia. Cancer Genet Cytogenet. 2008 May;183(1):49-52. PMID: #18474297#
Selvarajah S, Yoshimoto M, Prasad M, Shago M, Squire JA, Zielenska M, Somers GR.Characterization of trisomy 8 in pediatric undifferentiated sarcomas using advanced molecular cytogenetic techniques.Cancer Genet Cytogenet. 2007 Apr 1;174(1):35-41. PMID: #17350464#
Paulsson K, Johansson B. Trisomy 8 as the sole chromosomal aberration in acute myeloid leukemia and myelodysplastic syndromes. Pathol Biol (Paris). 2007 Feb;55(1):37-48. PMID: #16697122#
Schoch C, Kohlmann A, Dugas M, Kern W, Schnittger S, Haferlach T. Impact of trisomy 8 on expression of genes located on chromosome 8 in different AML subgroups. Genes Chromosomes Cancer. 2006 Dec;45(12):1164-8. PMID: #17001623#
Dodge W, Cruz J, Zamkoff K, Hurd D, Pettenati MJ. Use of fluorescence in situ hybridization to detect minimal residual disease in hematopoietic stem cell assays from peripheral blood stem cells of 2 patients with trisomy 8 acute myeloid leukemia. Stem Cells Dev. 2004 Feb;13(1):23-6. PMID: #15068690#
Batanian JR, Bridge JA, Wickert R, Vogler C, Gadre B, Huang Y. EWS/FLI-1 fusion signal inserted into chromosome 11 in one patient with morphologic features of Ewing sarcoma, but lacking t(11;22). Cancer Genet Cytogenet. 2002 Feb;133(1):72-5. PMID: #11890993#
Trisomy 8 as sole karyotypic aberration in an ovarian metastasizing Sertoli-Leydig cell tumor. Manegold E, Tietze L, Günther K, Fleischer A, Amo-Takyi BK, Schröder W, Handt S. Hum Pathol. 2001 May;32(5):559-62. PMID: #11381376#
VanDevanter DR, George D, McNutt MA, Vogel A, Luthardt F. Trisomy 8 in primary esthesioneuroblastoma. Cancer Genet Cytogenet. 1991 Nov;57(1):133-6. PMID: #1756479#