9p21 LOH

Alteration of the CDKN2A (alias p16) tumor suppressor gene, located on 9p21, occurs frequently in familial and sporadic melanomas.

Beside CDKN2A, other genes (e.g., CDKN2B, and ARF/p14(ARF), long considered distinct from CDKN2A) on this locus are often deleted or mutated in a large number of tumors including glioma, bladder cancer, and lung cancer.

Target genes

 CDKN2A (p16 or p16-INK4 and p14-ARF) (MIM.600160)
 CDKN2B (p15 or INK4B) (MIM.600431)
 ARF/p14(ARF)

Tumors

 melanomas
 head and neck epidermoid carcinomas

• correlation with recurrence (9484941)

 acute lymphoblastic leukemia (ALL)
 leiomyosarcomas
 gliomas
 bladder cancer (vesical carcinomas)
 lung cancer (pulmonary carcinomas)
 malignant peripheral nerve sheath tumors (MPNST) (10469453)
 pleural mesothelioma (23450849)

See also

 9p21 deletion
 LOHs

• 9p LOH

Open References

 Molecular alterations at chromosome 9p21 in melanocytic naevi and melanoma. Sini MC, Manca A, Cossu A, Budroni M, Botti G, Ascierto PA, Cremona F, Muggiano A, D’Atri S, Casula M, Baldinu P, Palomba G, Lissia A, Tanda F, Palmieri G. Br J Dermatol. 2008 Feb;158(2):243-50. PMID: 18028495 [Free]

References

 Morphology of 9p21 homozygous deletion-positive pleural mesothelioma cells analyzed using fluorescence in situ hybridization and virtual microscope system in effusion cytology. Matsumoto S, Nabeshima K, Kamei T, Hiroshima K, Kawahara K, Hata S, Marukawa K, Matsuno Y, Taguchi K, Tsujimura T. Cancer Cytopathol. 2013 Aug;121(8):415-22. doi : 10.1002/cncy.21269 PMID: 23450849

 Rákosy Z, Vízkeleti L, Ecsedi S, Bégány A, Emri G, Adány R, Balázs M. Characterization of 9p21 copy number alterations in human melanoma by fluorescence in situ hybridization. Cancer Genet Cytogenet. 2008 Apr 15;182(2):116-21. PMID: 18406873

 Berner JM, Sørlie T, Mertens F, Henriksen J, Saeter G, Mandahl N, Brøgger A, Myklebost O, Lothe RA. Chromosome band 9p21 is frequently altered in malignant peripheral nerve sheath tumors: studies of CDKN2A and other genes of the pRB pathway. Genes Chromosomes Cancer. 1999 Oct;26(2):151-60. PMID: 10469453