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salivary gland tumors
Monday 1 March 2004
salivary tumors; salivary gland neoplasms
See also : salivary glands
Images
Webpathology: http://www.webpathology.com/category.asp?category=19
Lesional patterns in salivary glands
inflammatory patterns
- mixed inflammatory pattern
- isolated lymphocytic infiltration
- granulomatous infiltration
- epithelial proliferation withou myopepithelial component
- epithelial proliferation with abundant myopepithelial component
- epithelial proliferation with a lymphoid background
- salivary gland tumors with basaloid appearance
Diagnosis by tumoral appearance
salivary gland tumors with squamous cell differentiation
salivary gland tumors with glandular pattern
- salivary gland tumors with acinar appearance
- salivary gland tumors with mucus production
- salivary gland tumors with cribroform pattern : cribriform salivary tumors
salivary gland tumors with basaloid appearance
clear cell salivary gland tumors
Epidemiology
Salivary gland neoplasms comprise less than 2% of all tumors in humans and 3% of all head and neck tumors. 80% of them are benign and only 20% are malignant.
Salivary gland neoplasms are relatively uncommon, with an overall incidence of 2.5 to 3 cases per 100,000 persons in the Western world.
The majority of these lesions (approximately 70%–80%) originate in the parotid gland.
Malignant salivary gland tumors are considerably less common; they account for approximately 3% to 5% of all head and neck cancers and have a tendency to present in the sixth or seventh decades of life.
Classification WHO 2017 - Tumours of the salivary glands
salivary epithelial benign tumors : salivary adenomas
- pleomorphic adenoma (mixed tumor )
- salivary myoepithelioma
- salivary basal cell adenoma
- Warthin tumor (papillary cystadenoma lymphomatosum )
- salivary oncocytoma
- salivary canalicular adenoma
- salivary sebaceous adenoma
- salivary lymphadenoma (sebaceous / non-sebaceous )
- salivary cystadenoma
- salivary ductal papillomas
- salivary inverted ductal papilloma
- salivary intraductal papilloma
- siladenoma papilliferum
malignant epithelial tumors : salivary carcinomas
- salivary acinic cell adenocarcinoma
- salivary mucoepidermoid carcinoma
- polymorphous low-grade adenocarcinoma
- salivary clear cell adenocarcinoma (NOS)
- salivary basal cell adenocarcinoma
- salivary sebaceous carcinoma
- salivary sebaceous lymphadenocarcinoma
- salivary cystadenocarcinoma
- salivary oncocytic carcinoma
- salivary duct carcinoma
- salivary gland adenocarcinoma (NOS)
- salivary myoepithelial carcinoma
- salivary carcinoma ex pleomorphic adenoma
- salivary carcinosarcoma
- metastasizing pleomorphic adenoma
- salivary squamous cell carcinoma
- salivary small cell carcinoma
- salivary large cell carcinoma
- salivary lymphoepithelial carcinoma
- sialoblastoma
NON-WHO 2017 entities
- mammary analogue secretory carcinoma (MASC)
- salivary cystadenocarcinoma
- salivary lymphadenocarcinoma
- salivary adenoid cystic carcinoma
- salivary mucinous adenocarcinoma
- malignant mixed tumor
- salivary carcinosarcoma
- salivary adenosquamous carcinoma
- salivary epithelial-myoepithelial carcinoma
- salivary small cell undifferenciated carcinoma (neuroendocrine features) (14763575)
- salivary gland anlage tumor (SGAT)
- salivary mesenchymal tumors
- osteoclast-type giant cell neoplasm of salivary gland
- salivary hemangioma
- salivary lipoma
- salivary lymphangioma
- salivary malignant schwannoma
- salivary hemangiopericytoma
- salivary malignat fibrous histiocytoma
- salivary lymphomas
- salivary metastatic tumors
Images
- salivary gland epithelial tumors
salivary epithelial benign tumors
- pleomorphic adenoma (mixed tumor)
- Warthin tumor (papillary cystadenoma lymphomatosum)
- salivary basal cell adenoma
- salivary myoepithelioma
- salivary canalicular adenoma
- salivary oncocytoma
- salivary cystadenoma
- salivary sebaceous adenoma
- siladenoma
- salivary lymphadenoma
- salivary ductal papillomas
- salivary intraductal papilloma
- salivary inverted ductal papilloma
- siladenoma papilliferum
salivary epithelial malignant tumors
- salivary acinic cell adenocarcinoma
- salivary basal cell adenocarcinoma
- salivary clear cell adenocarcinoma
- salivary cystadenocarcinoma
- salivary sebaceous adenocarcinoma
- salivary lymphadenocarcinoma
- salivary adenoid cystic carcinoma
- salivary mucinous adenocarcinoma
- malignant mixed tumor
- salivary carcinosarcoma
- salivary squamous cell carcinoma
- salivary mucoepidermoid carcinoma
- salivary adenosquamous carcinoma
- salivary epithelial-myoepithelial carcinoma
- salivary oncocytic carcinoma
- salivary duct carcinoma
- salivary myoepithelial carcinoma
- salivary small cell undifferenciated carcinoma (neuroendocrine features) (14763575)
- salivary gland anlage tumor (SGAT)
- salivary mesenchymal tumors
- osteoclast-type giant cell neoplasm of salivary gland
- salivary hemangioma
- salivary lipoma
- salivary lymphangioma
- salivary malignant schwannoma
- salivary hemangiopericytoma
- salivary malignat fibrous histiocytoma
- salivary lymphomas
- salivary metastatic tumors
Immunochemistry
Review and Updates of Immunohistochemistry in Selected Salivary Gland and Head and Neck Tumors. 2016
Variants
Diagnosis
epithelial tumors
- benign epithelial tumors
- myoepithelioma
- basal cell adenoma
- Warthin tumor
- oncocytoma
- canalicular adenoma
- lymphadenoma : sebaceous lymphadenoma / non-sebaceous lymphadenoma
- cystadenoma
- ductal papilloma
- intraductal papilloma
- sialadenoma papilliferum
- malignant epithelial tumors
- acinic cell carcinoma
- mucoepidermoidcarcinoma
- adenoid cystic carcinoma
- polymorphous low-grade adenocarcinoma
- epithelial-myoepithelial carcinoma
- clear cell carcinoma, NOS
- basal cell adenocarcinoma
- malignant sebaceous tumors (sebaceous carcinoma , sebaceous lymphadenocarcinoma )
- cystadenocarcinoma
- low-grade cribriform cystadenocarcinoma
- mucinous adenocarcinoma
- oncocytic carcinoma
- salivary duct carcinoma
- adenocarcinoma , NOS
- myoepithelial carcinoma
- carcinoma ex pleomorphic adenoma
- carcinosarcoma
- squamous cell carcinoma
- small cell carcinoma
- large cell carcinoma
- lymphoepithelial carcinoma
- sialoblastoma
mesenchymal tumors
- soft tissue tumors
- pleomorphic adenoma
- metastasizing pleomorphic adenoma
secondary tumors
Fusion genes in salivary tumors
PLAG1 rearrangements in pleomorphic adenoma
MAML2-TORC1 in MEC, WAT, clear cell hidradenoma
MYB-NFIB in ACC, dermal cylindroma
ATF1-EWSR1 in clear cell carcinoma
Links
Atlas of Salivary Gland Tumors by Faramarz Naeim, MD (UCLA)
See also
salivary glands
salivary gland pathology
salivary gland anomalies
pediatric epithelial salivary gland tumors
Open References
Immunohistochemical Analysis of Salivary Gland Tumors: Application for Surgical Pathology Practice. 2012. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496863/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496863/
https://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb9/bb9-chap5.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692207/
http://www.archivesofpathology.org/doi/full/10.5858/arpa.2016-0259-SA
Presentations
http://www.rosaicollection.org/pdfs/sem1354.pdf
http://www.ucsfcme.com/2017/MAP17001A/slides/18_Jordan_Salivary%20.pdf
Paywall References
Pediatric epithelial salivary gland tumors: Spectrum of histologies and cytogenetics at a Children’s Hospital. Craver RD, Fonseca P, Carr R. Pediatr Dev Pathol. 2010 Jan 7. PMID: 20055685
