salivary large cell carcinoma

Major salivary gland large-cell undifferentiated carcinoma (LCUC) is rare and has a poor prognosis. Large-cell undifferentiated carcinoma comprised @<@ 1% of all major salivary gland cancers.

In a series (#27545825 #), seventy percent of patients presented with advanced-stage disease. In this series, the incidence of occult nodal disease was 39%. Surgery followed by radiation was the most common treatment. Five-year overall survival was 36%.

The survival analysis demonstrates poorer survival in patients with positive surgical margins. Reported high rates of occult nodal disease also strongly support elective treatment of the neck.

See also

 salivary gland carcinomas / salivary carcinomas
 large cell carcinomas

Paywall references

 Predictors of outcomes in large cell undifferentiated carcinoma of the major salivary glands. Schrank TP, Zhan KY, Lentsch EJ. Laryngoscope. 2017 Feb;127(2):372-376. doi : 10.1002/lary.26136 PMID: 27545825