CGH losses

• 10q26.1-q26.3 loss
  20 January 2012

  Pathology
  Loss of 10q26.1-q26.3 in association with 7q34-q36.3 gain or 17q24.3-q25.3 gain predict poor outcome in pediatric medulloblastoma. (#21652146#)
  References
  Loss of 10q26.1-q26.3 in association with 7q34-q36.3 gain or 17q24.3-q25.3 gain predict poor outcome in pediatric medulloblastoma. Pezzolo A, Coco S, Raso A, Parodi F, Pistorio A, Valdora F, Capra V, Zollo M, Aschero S, Basso E, Cama A, Nozza P, Gambini C, Cinalli G, Garrè ML, Iolascon A, Pistoia V, Tonini GP. Cancer Lett. (...)

• 6q loss
  9 September 2010

  Chromosome arm 6q loss is the most common recurrent autosomal alteration detected in primary pediatric ependymoma.
  Loss of chr 6q is mainly observed in infratentorial ependymoma and World Health Organization (WHO) grade 3 ependymomas.
  References
  Reardon DA, Entrekin RE, Sublett J, Ragsdale S, Li H, Boyett J, Kepner JL, Look AT (1999) Chromosome arm 6q loss is the most common recurrent autosomal alteration detected in primary pediatric ependymoma. Genes Chromosomes Cancer (...)

• 9p loss
  14 October 2009

  Pathology
  Loss of chromosome 9p is an independent prognostic factor in patients with clear cell renal cell carcinoma (clear cell RCC). (#17906617#)
  References
  Loss of chromosome 9p is an independent prognostic factor in patients with clear cell renal cell carcinoma. Brunelli M, Eccher A, Gobbo S, Ficarra V, Novara G, Cossu-Rocca P, Bonetti F, Menestrina F, Cheng L, Eble JN, Martignoni G. Mod Pathol. 2008 Jan;21(1):1-6. PMID: (...)

• 13q loss
  15 October 2008

  Tumors
  dedifferentiated hepatocellular carcinoma (#18820673#) 6 genes (BIC, CPNE1, RBPMS, RFC4, RPSA, TOP2A) are among the 20 most significantly upregulated genes both in dedifferentiated carcinoma and in carcinoma with loss of 13q. (#18820673#)
  References
  Skawran B, Steinemann D, Becker T, Buurman R, Flik J, Wiese B, Flemming P, Kreipe H, Schlegelberger B, Wilkens L. Loss of 13q is associated with genes involved in cell cycle and proliferation in dedifferentiated hepatocellular (...)

• Chr.18 loss
  21 September 2007

  Tumors
  prostatic carcinomas
  References
  Gagnon A, Ripeau JS, Zvieriev V, Chevrette M. Chromosome 18 suppresses tumorigenic properties of human prostate cancer cells. Genes Chromosomes Cancer. 2006 Mar;45(3):220-30. PMID: #16281261#

• 16q loss
  17 September 2007

  Tumors
  Wilms tumor (#16518847#)
  mammary carcinomas (#16518845#)
  See also
  16q LOH
  References
  Watanabe N, Nakadate H, Haruta M, Sugawara W, Sasaki F, Tsunematsu Y, Kikuta A, Fukuzawa M, Okita H, Hata J, Soejima H, Kaneko Y. Association of 11q loss, trisomy 12, and possible 16q loss with loss of imprinting of insulin-like growth factor-II in Wilms tumor. Genes Chromosomes Cancer. 2006 Jun;45(6):592-601. PMID: #16518847#
  Rakha EA, Green AR, Powe DG, Roylance R, Ellis IO. Chromosome (...)

• 11q loss
  17 September 2007

  References
  Parikh RA, White JS, Huang X, Schoppy DW, Baysal BE, Baskaran R, Bakkenist CJ, Saunders WS, Hsu LC, Romkes M, Gollin SM. Loss of distal 11q is associated with DNA repair deficiency and reduced sensitivity to ionizing radiation in head and neck squamous cell carcinoma. Genes Chromosomes Cancer. 2007 May 10;46(8):761-775 PMID: #17492757#
  Wittmann S, Zirn B, Alkassar M, Ambros P, Graf N, Gessler M. Loss of 11q and 16q in Wilms tumors is associated with anaplasia, tumor (...)

• 10q loss
  26 June 2007

  Tumors
  sclerosing rhabdomyosarcoma (#17016719#)
  Regions
  10q22 loss
  See also
  Oncobase
  10q deletion
  10q LOH
  References
  Kuhnen C, Herter P, Leuschner I, Mentzel T, Druecke D, Jaworska M, Johnen G. Sclerosing pseudovascular rhabdomyosarcoma-immunohistochemical, ultrastructural, and genetic findings indicating a distinct subtype of rhabdomyosarcoma. Virchows Arch. 2006 Nov;449(5):572-8. PMID: (...)

• 10q22 loss
  26 June 2007

  Tumors
  sclerosing rhabdomyosarcoma (#17016719#)
  See also
  Oncobase
  10q22 deletion
  10q22 LOH
  References
  Kuhnen C, Herter P, Leuschner I, Mentzel T, Druecke D, Jaworska M, Johnen G. Sclerosing pseudovascular rhabdomyosarcoma-immunohistochemical, ultrastructural, and genetic findings indicating a distinct subtype of rhabdomyosarcoma. Virchows Arch. 2006 Nov;449(5):572-8. PMID: (...)

• 1q loss
  26 June 2007

  Tumors
  gastrointestinal stromal tumor (GIST) (#17330260#)
  neuroblastomas
  See also
  1q deletion
  1q LOH

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