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sclerosing angiomatoid nodular transformation
Tuesday 4 April 2006
Definition: Splenic angiomatoid nodules as altered red pulp tissue entrapped by a nonneoplastic stromal proliferative process. The characteristic morphologic appearance, immunophenotype, and benign clinical course suggest that this is a distinctive nonneoplastic vascular lesion of the spleen.
References
Martel M, Cheuk W, Lombardi L, Lifschitz-Mercer B, Chan JK, Rosai J. Sclerosing angiomatoid nodular transformation (SANT): report of 25 cases of a distinctive benign splenic lesion. Am J Surg Pathol. 2004 Oct;28(10):1268-79. PMID: 15371942