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splenic amyloidosis

Sunday 19 May 2013

spleen amyloidosis

PO

Synopsis

Macroscopy

 firm consistency
 waxy consistency
 possible sago spleen
 possible lardaceous spleen
 splenomegaly
 diffuse splenic infiltration
 possible localized splenic nodules
 rare splenic rupture

Microscopy

 splenic deposition of pink amorphous material

  • deposition of pink amorphous material limited either to germinal follicles (sago spleen)
  • deposition of pink amorphous material along splenic sinusoids
  • deposition of pink amorphous material in surrounding connective tissue (lardaceous spleen)

 splenic deposition of amyloid (amyloidosis)

  • deposition of amyloid limited either to germinal follicles (sago spleen)
  • deposition of amyloid along splenic sinusoids
  • deposition of amyloid in surrounding connective tissue (lardaceous spleen)

Etiology

 amyloidosis

  • mostly secondary amyloidosis
  • rare primary amyloidosis

See also

 splenic diseases
 amyloidosis