Home > G. Tumoral pathology > Cancer molecular profiling > Cancer cytogenetics > Tumoral translocations > t(4;14)(p16;q32)
t(4;14)(p16;q32)
Friday 10 February 2006
Tumors
plasma cell leukemia multiple myeloma plasmacytoma lymphoma showing the immunophenotype of chronic lymphocytic leukemia (20620602) monoclonal gammopathy of unknown significance (MGUS)
Molecular biology
FGFR3-IGH rearrangements
References
Detection of a t(4;14)(p16;q32) in two cases of lymphoma showing both the immunophenotype of chronic lymphocytic leukemia. Bacher U, Haferlach T, Schnittger S, Weiss T, Burkhard O, Bechtel B, Kern W, Haferlach C. Cancer Genet Cytogenet. 2010 Jul 15;200(2):170-4. PMID: 20620602
The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells. Martinez-Garcia E, Popovic R, Min DJ, Sweet SM, Thomas PM, Zamdborg L, Heffner A, Will C, Lamy L, Staudt LM, Levens DL, Kelleher NL, Licht JD. Blood. 2011 Jan 6;117(1):211-20. PMID: 20974671