Home > G. Tumoral pathology > Molecular pathology of tumors > Genetic anomalies > LOH by regions > 18q21 LOH
18q21 LOH
Thursday 5 January 2006
Tumors (Exemples)
colorectal adenocarcinoma
clear cell renal cell carcinoma (19%)
pulmonary carcinomas (lung cancer)
Target region
18q21.3 (18q21 LOH)
- candidate gene: DCC, SMAD4
Candidate genes
DCC at 18q21
SMAD4 at 18q21
See also
loss of heterozygosity (LOH)
inactivation of tumor suppressor genes