LMO2

Pathology

 DLBCL prognosis

• Both LMO2 (LIM domain only 2) mRNA and protein expression in diffuse large B-cell lymphoma (DLBCL) have been associated with superior survival. (22066713)
• Germline genetic variation in LMO2 is associated with DLBCL prognosis and provided slightly stronger predictive ability relative to LMO2 IHC status. (22066713)

 11q13 translocation in T-cell acute lymphoblastic leukemia

• t(7;11)(q35;p13) (TCRB/LMO2) (TCRB at 7q35/LMO2 at 11p13)
• t(11;14)(p13;q11) (LMO2/TCRA) (LMO2 at 11p13/TCRA at 14q11)

Immunochemistry

 LMO2 in the detection of the interfollicular and diffuse components of follicular B-cell lymphomas (20697248)

References

 Detection of LIM domain only 2 (LMO2) in normal human tissues and haematopoietic and non-haematopoietic tumours using a newly developed rabbit monoclonal antibody. Agostinelli C, Paterson JC, Gupta R, Righi S, Sandri F, Piccaluga PP, Bacci F, Sabattini E, Pileri SA, Marafioti T. Histopathology. 2012 Jul;61(1):33-46. PMID: 22394247

 LIM domain only 2 protein expression, LMO2 germline genetic variation, and overall survival in diffuse large B-cell lymphoma in the pre-rituximab era. Cerhan JR, Natkunam Y, Morton LM, Maurer MJ, Asmann Y, Habermann TM, Vasef MA, Cozen W, Lynch CF, Allmer C, Slager SL, Lossos IS, Chanock SJ, Rothman N, Hartge P, Dogan A, Wang SS. Leuk Lymphoma. 2012 Jan 3. PMID: 22066713

 Immunoarchitectural Patterns in Follicular Lymphoma: Efficacy of HGAL and LMO2 in the Detection of the Interfollicular and Diffuse Components. Younes SF, Beck AH, Lossos IS, Levy R, Warnke RA, Natkunam Y. Am J Surg Pathol. 2010 Sep;34(9):1266-76. PMID: 20697248