ovarian round cell tumors

Examples

 ovarian gonadoblastoma

• Gonadoblastoma has ovarian stroma surrounding nests of germ cells and sex cord stromal cells, with frequent hyalinization and calcification.
• It is the most frequent tumor found in gonadal dysgenesis, usually a phenotypic female with an XY karyotype and streak gonads.
• Gonadoblastoma is the most common tumor found in gonadal dysgenesis , most commonly a phenotypic female with XY chromosomes.

 ovarian granulosa cell tumor

• Granulosa cell tumor has sheets small cells with longitudinal nuclear grooves (“coffee bean nuclei”), and Call-Exner bodies (eosinophilic fluid filled spaces surrounded by granulosa cells).
• Most tumors cause hyperestrogenism.

 ovarian dysgerminoma

• Gonadoblastoma can have cells resembling dysgerminoma.
• Dysgerminoma (seminoma) has fibrous septae infiltrated by lymphocytes, and tumor cells with clear cytoplasm.
• It tends to arise out of intratubular germ cell neoplasia ( ITGCN ).
• If syncytiotrophoblast is present, it may also have elevated hCG, but usually not as high as choriocarcinoma.

 ovarian clear cell adenocarcinoma

• The lesion has large pleomorphic cells with clear cytoplasm and are hobnailed and cuboidal. Mitoses are usually infrequent.
• The papillary and fibrous cores are hyalinized.
• These findings are consistent with clear cell adenocarcinoma.
• It is associated with VHL mutations.
• Endometriosis is associated with clear cell adenocarcinoma and endometrioid adenocarcinoma.

See also

 ovarian tumors

• ovarian carcinomas
• ovarian papillary tumors

 round cell tumors