nuclear grooves

Wednesday 22 February 2017

nuclear groove; nuclear grooving

See also : coffee bean nuclei

Images

https://twitter.com/KCampbellMD/status/1083878820850139136

Examples

papillary thyroid carcinoma (PTC). Grooves & classic "orphan Annie eye" (empty round nuclei)

Tumor types

papillary thyroid carcinoma

Nuclear grooving is a useful morphologic feature in the diagnosis of papillary carcinoma of the thyroid (PTC) in tissue sections and imprint smears.
Nuclear grooving, when seen in abundance, can be considered a reliable criterion for the diagnosis of papillary carcinoma in fine needle aspiration cytology of the thyroid.
The presence of occasional grooves, however, should be regarded as a nonspecific finding.

Langerahns histiocytosis

Granulosa cell tumor has sheets of small cells with longitudinal nuclear grooves (“coffee bean nuclei”), and Call-Exner bodies (eosinophilic fluid filled spaces surrounded by granulosa cells). Most tumors cause hyperestrogenism.

See also

PMID: 2916367

Examples

papillary thyroid carcinoma
ovarian benign Brenner tumor

Images

ovarian benign Brenner tumor

See also

nuclear anomalies

B. Cellular pathology