ovarian spindle cell tumors

Examples

 ovarian fibroma

• Ovarian fibroma has dense benign spindle cells.
• It is associated with Meigs syndrome (ovarian fibroma, ascites, right pleural effusion), and Gorlin syndrome (basal cell nevus syndrome - basal cell carcinomas, odontogenic keratocyst , PTCH gene, autosomal dominant).

 fibrothecoma

• Fibrothecoma has features of fibroma and thecoma.

 thecoma

• Thecoma has lipid vacuolated spindle cells with hyaline plaques.
• They can produce estrogens and androgens.

 ovarian fibrosarcoma

• Fibrosarcoma has a herringbone pattern, cellular atypia, and increased mitoses.

 Brenner tumor

• Brenner tumor contains nests of urothelial type cells with distinct outlines, nuclei with longitudinal grooves (“coffee bean”) and a dense fibroblastic stroma.
• Brenner tumor can be benign, borderline or malignant depending on the cytologic morphology and behavior.

See also

 ovarian tumors
 spindle cell tumors