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CIC-DUX4
Tuesday 1 November 2016
DUX4-CIC
Molecular biology
CIC-DUX4 gene fusion in Ewing-like sarcoma
- Ewing-like sarcomas with t(4;19)(q35;q13)
- Fusion between CIC and DUX4 up-regulates PEA3 family genes in Ewing-like sarcomas with t(4;19)(q35;q13) translocation.
- fusion gene between DUX4 at 4q35 (MIM.606009) and CIC at 19q35 by t(4;19)(q35;q13) (16717057)
- CIC, a human homolog of Drosophila capicua which encodes a high mobility group box transcription factor, is fused to a double homeodomain gene DUX4 as a result of a recurrent chromosomal translocation t(4;19)(q35;q13).
CIC-DUX4 gen fusion in primary undifferentiated sarcoma of the kidney (27340751)
IHC
DUX4 immunostaining distinguishes CIC-DUX4 tumors from other round cell mimics. Recommended use when CIC-DUX4 fusion-positive round cell tumor enters the histologic differential diagnosis. (27879517)
Paywall references
DUX4 Immunohistochemistry is a Highly Sensitive and Specific Marker for CIC-DUX4 Fusion-positive Round Cell Tumor. Siegele B, Roberts J, Black JO, Rudzinski E, Vargas SO, Galambos C. Am J Surg Pathol. 2016 Nov 22. PMID: 27879517