single-cell analysis in cancer

Single-cell approaches are used to study EMT-related markers of CTCs for metastatic prostate cancer detection and prediction. Markers are identified using microfluidics and atomic force microscope (AFM) for molecular profiling and nanomechanical and nanochemical phenotypes of CTCs, respectively.

Reference

 Direct, genome-wide assessment of DNA mutations in single cells. Gundry M, Li W, Maqbool SB, Vijg J. Nucleic Acids Res. 2012 Mar;40(5):2032-40. doi : 10.1093/nar/gkr949 PMID: 22086961