prostatic tumors

WHO histological classification of tumours of the prostate

 prostatic epithelial tumors

• prostatic glandular tumors
  • prostatic adenocarcinoma (prostatic acinar adenocarcinoma) ICD-0:8140/31
    • prostatic atrophic adenocarcinoma
    • prostatic pseudohyperplastic adenocarcinoma
    • prostatic foamy adenocarcinoma
    • prostatic colloid adenocarcinoma ICD-0:8480/3
    • prostatic signet ring adenocarcinoma ICD-0:8490/3
    • prostatic oncocytic adenocarcinoma ICD-0:8290/3
    • prostatic lymphoepithelioma-like adenocarcinoma ICD-0:8082/3

• • prostatic carcinoma with spindle cell differentiation (prostatic spindle cell carcinoma) : (carcinosarcoma, sarcomatoid carcinoma) ICD-0:8572/3

• • prostatic intraepithelial neoplasia (PIN)
  • prostatic intraepithelial neoplasia, grade III (PIN III) ICD-0:8148/2
  • prostatic ductal adenocarcinoma ICD-0:8500/3
    • prostatic cribriform adenocarcinoma ICD-0:8201/3
    • prostatic papillary adenocarcinoma ICD-0:8260/3
    • prostatic solid adenocarcinoma ICD-0:8230/3

• prostatic urothelial tumors
  • prostatic urothelial carcinoma ICD-0:8120/3

• prostatic squamous tumors
  • prostatic adenosquamous carcinoma ICD-0:8560/3
  • prostatic squamous cell carcinoma ICD-0:8070/3

• prostatic basal cell tumors
  • prostatic basal cell adenoma ICD-0:8147/0
  • prostatic basal cell carcinoma ICD-0:8147/3

 prostatic neuroendocrine tumors

• prostatic endocrine differentiation within adenocarcinoma ICD-0:8574/3
• prostatic carcinoid tumour ICD-0:8240/3
• prostatic small cell carcinoma ICD-0:8041/3
• prostatic paraganglioma ICD-0:8680/1
• prostatic neuroblastoma ICD-0:9500/3

 prostatic stromal tumors

• prostatic stromal tumour of uncertain malignant potential ICD-0:8935/1
• prostatic stromal sarcoma ICD-0:8935/3

 prostatic mesenchymal tumors

• prostatic leiomyosarcoma ICD-0:8890/3
• prostatic thabdomyosarcoma ICD-0:8900/3
• prostatic chondrosarcoma ICD-0:9220/3
• prostatic angiosarcoma ICD-0:9120/3
• prostatic malignant fibrous histiocytoma ICD-0:8830/3
• prostatic malignant peripheral nerve sheath tumour ICD-0:9540/3
• prostatic hemangioma ICD-0:9120/0
• prostatic chondroma ICD-0:9220/0
• prostatic leiomyoma ICD-0:8890/0
• prostatic granular cell tumour ICD-0:9580/0
• prostatic hemangiopericytoma ICD-0:9150/1
• prostatic solitary fibrous tumour ICD-0:8815/0

 prostatic mematolymphoid tumors

• prostatic lymphoma
• prostatic leukemia

 prostatic miscellaneous tumours

• prostatic cystadenoma ICD-0:8440/0
• prostatic nephroblastoma (Wilms tumour) ICD-0:8960/3
• prostatic malignant rhabdoid tumour ICD-0:8963/3
• prostatic Germ cell tumors
  • prostatic Yolk sac tumor ICD-0:9071/3
  • prostatic seminoma ICD-0:9061/3
  • prostatic embryonal carcinoma & teratoma ICD-0:9081/3
  • prostatic choriocarcinoma ICD-0:9100/3

• prostatic clear cell adenocarcinoma ICD-0:0/3
• prostatic Melanoma ICD-0:8720/3

 prostatic metastatic tumours
 prostatic tumors of the seminal vesicles

 prostatic epithelial tumors

• prostatic adenocarcinoma ICD-0:8140/3
• prostatic cystadenoma ICD-0:8440/0

 prostatic mixed epithelial and stromal tumors

• prostatic malignant mixed epithelial and stromal tumors
• prostatic benign mixed epithelial and stromal tumors

 prostatic mesenchymal tumours

• prostatic leiomyosarcoma ICD-0:8890/3
• prostatic angiosarcoma ICD-0:9120/3
• prostatic liposarcoma ICD-0:8850/3
• prostatic malignant fibrous histiocytoma ICD-0:8830/3
• prostatic solitary fibrous tumour ICD-0:8815/0
• prostatic hemangiopericytoma ICD-0:9150/1
• prostatic leiomyoma ICD-0:8890/0

 prostatic miscellaneous tumours

• prostatic choriocarcinoma ICD-0:9100/3
• prostatic male adnexal tumour of probable Wolffian origin

 prostatic metastatic tumors

TNM classification of carcinomas of the prostate

T – Primary tumour

 TX Primary tumour cannot be assessed
 T0 No evidence of primary tumour
 T1 Clinically inapparent tumour not palpable or visible by imaging
 * T1a Tumour incidental histological finding in 5% or less of tissue
resected
 * T1b Tumour incidental histological finding in more than 5% of tissue
resected
 * T1c Tumour identified by needle biopsy (e.g., because of elevated
PSA)

 T2 Tumour confined within prostate (Tumour found in one or both lobes by needle biopsy, but not palpable or visible by imaging, is classified as T1c.)
 * T2a Tumour involves one half of one lobe or less
 * T2b Tumour involves more than half of one lobe, but not both lobes
 * T2c Tumour involves both lobes

 T3 Tumour extends beyond the prostate (Invasion into the prostatic apex yet not beyond the prostate is not classified as T3, but as T2.)
 * T3a Extracapsular extension (unilateral or bilateral)
 * T3b Tumour invades seminal vesicle(s)

 T4 Tumour is fixed or invades adjacent structures other than sem
inal vesicles: bladder neck, external sphincter, rectum, levator
muscles, or pelvic wall (Microscopic bladder neck involvement at radical prostatectomy should be classified as T3a.)

Note: There is no pT1 category because there is insufficient tissue to assess the highest pT category.

N – Regional lymph nodes

 NX Regional lymph nodes cannot be assessed
 N0 No regional lymph node metastasis
 N1 Regional lymph node metastasis

Note: Metastasis no larger than 0.2cm can be designated pN1mi

M – Distant metastasis

 MX Distant metastasis cannot be assessed
 M0 No distant metastasis
 M1 Distant metastasis
 M1a Non-regional lymph node(s)
 M1b Bone(s)
 M1c Other site(s)

G Histopathological grading

GX Grade cannot be assessed
G1 Well differentiated (Gleason 2-4)
G2 Moderately differentiated (Gleason 5-6)
G3–4 Poorly differentiated/undifferentiated (Gleason 7-10)

Stage grouping

Stage I T1a N0 M0 G1
Stage II T1a N0 M0 G2, 3–4
T1b, c N0 M0 Any G
T1, T2 N0 M0 Any G
Stage III T3 N0 M0 Any G
Stage IV T4 N0 M0 Any G
Any T N1 M0 Any G
Any T Any N M1 Any G

See also

 prostatic non-epithelial tumors

• prostatic mesenchymal tumors

 Cancer
 Tumors

References

 Non-epithelial neoplasms of the prostate. Paner GP, Aron M, Hansel DE, Amin MB. Histopathology. 2012 Jan;60(1):166-86. PMID: 22212085