prostatic clear cell adenocarcinoma

There are single case reports of renal-type clear cell carcinoma, tubulocystic clear cell adenocarcinoma of the prostate, and clear cell adenocarcinoma resembling Mullerian/urethral adenocarcinoma arising in the prostatic utricle.

Microscopy

 tubulocystic and papillary glands lined by glycogen-rich, cuboidal or hobnail cells with clear to eosinophilic cytoplasm
 enlarged nuclei with mild pleomorphism and prominent nucleoli
 may have prominent vasculature, inflammatory infiltrate, hyaline globules, psammoma bodies
 resembles ovarian neoplasm

Differential diagnosis

 urothelial carcinoma : clear cell variant
 renal cell carcinoma : metastatic; history of renal primary
 nephrogenic adenoma

• tubules composed of single layer of cuboidal or flattened cells with clear to eosinophilic cytoplasm
• round nuclei with fine chromatin

References

 Histological variants of prostatic carcinoma and their significance. Humphrey PA. Histopathology. 2012 Jan;60(1):59-74. PMID: 22212078