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MALDI imaging
Wednesday 23 December 2009
Histopathology proteomics adds the mass spectrometer to the arsenal of tools for the direct analysis of tissue biopsies and molecular diagnosis.
Typically called MALDI imaging, this technique takes mass spectral snapshots of intact tissue slices, revealing how proteins and peptides are spatially distributed within a given sample.
References
Tissue imaging using MALDI-MS: a new frontier of histopathology proteomics. Fournier I, Wisztorski M, Salzet M. Expert Rev Proteomics. 2008 Jun;5(3):413-24. PMID: 18532909
In situ molecular imaging of proteins in tissues using mass spectrometry. Hardesty WM, Caprioli RM. Anal Bioanal Chem. 2008 Jun;391(3):899-903. PMID: 18365184