Biotechnology

• TALENs
  26 December 2012

  transcription activator–like effector nucleases
  In 2012, genome engineers got their hands on some potentially powerful new tools that promise to put the modification of DNA within easy reach of biologists studying a variety of organisms, including yeast and humans.
  Zinc-finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs) comprise a powerful class of tools that are redefining the boundaries of biological research.
  These chimeric nucleases are composed of (...)

• zinc-finger nuclease gene targeting
  25 November 2011

  Zinc-finger nuclease gene engineering, ZFN gene targeting, ZFN gene engineering; ZFNs
  Zinc-finger nuclease (ZFN) gene targeting is emerging as a versatile tool for engineering of multiallelic gene deficiencies.
  Something closer to the clinic is the zinc-finger nuclease, an enzyme created by the fusion of zinc finger DNA-binding domains with an endonuclease’s cleavage domain.
  The modularity of zinc fingers allows for predictable customization of the DNA that the nuclease recognizes and (...)

• zinc-finger nucleases
  18 October 2011

  Something closer to the clinic is the zinc-finger nuclease, an enzyme created by the fusion of zinc finger DNA-binding domains with an endonuclease’s cleavage domain.
  The modularity of zinc fingers allows for predictable customization of the DNA that the nuclease recognizes and cuts, and there are kits for making the process easier.
  Such nucleases form the basis for Sangamo’s HIV treatment, SB-728-T. It consists of removing T cells and treating them with the nucleases to introduce a (...)

• biocircuits
  18 October 2011

  A large portion of synthetic biology research is concerned with making tools. They apply complementary informatics, design, and genetic engineering approaches to the problem of genetic circuits.
  Also, databases such as the Parts Registry encourage cataloguing such data. Finding enough genetic parts there for a novel function, however, is still a long way away.
  Tools such as GenoCAD, ProMoT, and others allow user-friendly design of circuits, SynBioSS allows in silico chemical simulation of (...)

• very small embryonic-like stem cells
  17 October 2011

  VSELs

• chitin
  17 October 2011

  Chitin scaffolds
  Tissue engineering/regeneration is based on the hypothesis that healthy stem/progenitor cells either recruited or delivered to an injured site, can eventually regenerate lost or damaged tissue.
  Most of the researchers working in tissue engineering and regenerative technology attempt to create tissue replacements by culturing cells onto synthetic porous three-dimensional polymeric scaffolds, which is currently regarded as an ideal approach to enhance functional tissue (...)

• tooth regeneration
  17 October 2011

  Regenerative endodontics

• adipose-derived stem cells
  17 October 2011

  adipose-derived stem cell

• stem cell therapy
  17 October 2011

  stem cell therapies.

• human cell arrays
  17 October 2011

  human cell chips

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