oncogenes

Pathology

 activation mutation
 overexpression

• fusion gene in which the promoter region of genes coding for the subunits of immunoglobulins (IGHG1, IGLC1, IGKC) or TCR (TCRA, TCRB, TCRC, TCRD) are juxtaposed to the entire coding sequence of a second gene that is subsequently overexpressed in lymphoid cells causing lymphomas or lymphoid leukemias

• fusion gene in which the promoter region of a first gene is juxtaposed to the entire coding sequence of a second gene that is subsequently overexpressed in specific tissue

• • Exemple: fusion gene in which the osteoblast cadherin 11 gene (CDH11) promoter region on 16q22 is juxtaposed to the entire ubiquitin-specific protease USP6 (Tre2) coding sequence on 17p13 with USP6 overexpression in aneurysmal bone cyst (15026324)

References

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 Hammond SM. MicroRNAs as oncogenes. Curr Opin Genet Dev. 2006 Feb;16(1):4-9. PMID: 16361094

 Prive GG, Melnick A. Specific peptides for the therapeutic targeting of oncogenes. Curr Opin Genet Dev. 2006 Feb;16(1):71-7. PMID: 16377176

 Vogelstein B, Kinzler KW. Cancer genes and the pathways they control. Nat Med. 2004 Aug;10(8):789-99. PMID: 15286780

 Futreal PA, Coin L, Marshall M, Down T, Hubbard T, Wooster R, Rahman N, Stratton MR. A census of human cancer genes. Nat Rev Cancer. 2004 Mar;4(3):177-83. PMID: 14993899

 Felsher DW. Reversibility of oncogene-induced cancer. Curr Opin Genet Dev. 2004 Feb;14(1):37-42. PMID: 15108803

 Felsher DW. Cancer revoked: oncogenes as therapeutic targets. Nat Rev Cancer. 2003 May;3(5):375-80. PMID: 12724735

 Hueber AO, Evan GI. Traps to catch unwary oncogenes. Trends Genet. 1998 Sep;14(9):364-7. PMID: 9769732