Accueil > G. Tumoral pathology > Cancer molecular profiling > Cancer cytogenetics > Tumoral translocations > t(5 ;9)(q33 ;q22)
t(5 ;9)(q33 ;q22)
jeudi 26 mars 2009
Tumors
peripheral T-cell lymphomas with follicular growth pattern (18%)
- Rare cases of peripheral T-cell lymphomas with follicular growth pattern (PTCL-F) have been reported. Their association with t(5 ;9)(q33 ;q22) involving ITK and SYK has been suggested. This rare form of PTCL has an immunophenotype indicative of derivation from TFH cells. It is associated with t(5 ;9) in a proportion of cases. It shows some overlapping features with angioimmunoblastic T-cell lymphoma, raising the question of a possible relationship.
Open References
The ITK-SYK fusion oncogene induces a T-cell lymphoproliferative disease in mice mimicking human disease. Dierks C, Adrian F, Fisch P, Ma H, Maurer H, Herchenbach D, Forster CU, Sprissler C, Liu G, Rottmann S, Guo GR, Katja Z, Veelken H, Warmuth M. Cancer Res. 2010 Aug 1 ;70(15):6193-204. doi : 10.1158/0008-5472.CAN-08-3719 PMID : 20670954 [Free]
The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma. Pechloff K, Holch J, Ferch U, Schweneker M, Brunner K, Kremer M, Sparwasser T, Quintanilla-Martinez L, Zimber-Strobl U, Streubel B, Gewies A, Peschel C, Ruland J. J Exp Med. 2010 May 10 ;207(5):1031-44. doi : 10.1084/jem.20092042 PMID : 20439541 [Free]
Peripheral T cell lymphoma : new model + new insight. Mulloy JC. J Exp Med. 2010 May 10 ;207(5):911-3. doi : 10.1084/jem.20100608 PMID : 20439538 [Free]
References
ITK/SYK Translocation in Angioimmunoblastic T-cell Lymphoma. Attygalle AD, Feldman AL, Dogan A. Am J Surg Pathol. 2013 Sep ;37(9):1456-7. doi : 10.1097/PAS.0b013e3182991415 PMID : 24076779
Peripheral T-cell Lymphomas With a Follicular Growth Pattern are Derived From Follicular Helper T Cells (TFH) and may Show Overlapping Features With Angioimmunoblastic T-cell Lymphomas. Huang Y, Moreau A, Dupuis J, Streubel B, Petit B, Le Gouill S, Martin-Garcia N, Copie-Bergman C, Gaillard F, Qubaja M, Fabiani B, Roncador G, Haioun C, Delfau-Larue MH, Marafioti T, Chott A, Gaulard P. Am J Surg Pathol. 2009 Mar 17. PMID : 19295409
Novel t(5 ;9)(q33 ;q22) fuses ITK to SYK in unspecified peripheral T-cell lymphoma. Streubel B, Vinatzer U, Willheim M, Raderer M, Chott A. Leukemia. 2006 Feb ;20(2):313-8. PMID : 16341044