Home > G. Tumoral pathology > Molecular pathology of tumors > Genetic anomalies > Cancer cytogenetics > Tumoral translocations > t(1;3)(q25;q27)
t(1;3)(q25;q27)
Monday 19 May 2008
Tumors
B-cell lymphoma. Cancer Genet Cytogenet. 2008 Apr 15;182(2):144-9. PMID: 18406879
GAS5
The GAS5 (growth arrest-specific transcript 5) gene can be a partner of BCL6 in diffuse large B-cell lymphoma, harboring the t(1;3)(q25;q27).
The GAS5 gene on chromosome 1q25 is the second BCL6 partner, to the SNHG5 on 6q15, which is classified as a non-protein-coding multiple snoRNA host and 5’-TOP class gene.
BCL6
The BCL6 gene is frequently disrupted at its 5’ noncoding region by 3q27 chromosomal translocations in B-cell lymphoma. As a result of translocation, BCL6 is juxtaposed to reciprocal partners, such as the immunoglobulin (Ig) gene family. Besides the Ig loci, multiple non-Ig partners of the BCL6 translocation have been reported.
References
Nakamura Y, Takahashi N, Kakegawa E, Yoshida K, Ito Y, Kayano H, Niitsu N, Jinnai I, Bessho M. The GAS5 (growth arrest-specific transcript 5) gene fuses to BCL6 as a result of t(1;3)(q25;q27) in a patient with B-cell lymphoma. Cancer Genet Cytogenet. 2008 Apr 15;182(2):144-9. PMID: 18406879