salivary gland marginal zone lymphoma
Clinical synopsis
mostly adults (>50)
female predominance
recurrent episodes of salivary gland swelling
Microscopical synopsis
plasma cell infiltration
Predisposition - Risk factors - Associations
dysimmunity
autoimmunity
- Sjogren syndrome (Sjögren syndrome)
myoepithelial sialadenitis
gastric MALT lymphoma
post-transplantation (#10632493#)
chronic sclerosing sialadenitis (Kuttner tumor) (#11717546#)
Differential diagnosis
Differential diagnosis
lymphoepithelial sialadenitis (LESA) (myoepithelial sialedenitis)
lymphoepithelial cystic hyperplasia
- HIV-associated lymphoepithelial cystic hyperplasia
- non-HIV-associated lymphoepithelial cystic hyperplasia
salivary lymphomas
- salivary diffuse small B-cell lymphomas (DSBCL)
- follicular lymphoma
- mantle cell lymphoma
- peripheral T-cell lymphoma
- lymphoblastic lymphoma
Cytogenetics
t(11;18)(q21;q21) (API2/MALT1 fusion gene) (30-50% of the low-grade MALT)
t(1;14)(p21;q32) in extra-nodal MALT lymphoma
trisomy 3 (#7718871#) and +3q (30-70% of the cases) in nodal, extra-nodal and splenic MZBCL
See also
marginal zone lymphomas
References
Ochoa ER, Harris NL, Pilch BZ. Marginal zone B-cell lymphoma of the salivary gland arising in chronic sclerosing sialadenitis (Kuttner tumor). Am J Surg Pathol. 2001 Dec;25(12):1546-50. PMID: #11717546#
Hsi ED, Singleton TP, Swinnen L, Dunphy CH, Alkan S. Mucosa-associated lymphoid tissue-type lymphomas occurring in post-transplantation patients. Am J Surg Pathol. 2000 Jan;24(1):100-6. PMID: #10632493#
Bailey EM, Ferry JA, Harris NL, Mihm MC Jr, Jacobson JO, Duncan LM. Marginal zone lymphoma (low-grade B-cell lymphoma of mucosa-associated lymphoid tissue type) of skin and subcutaneous tissue: a study of 15 patients. Am J Surg Pathol. 1996 Aug;20(8):1011-23. PMID: #8712288#
Diss TC, Wotherspoon AC, Speight P, Pan L, Isaacson PG. B-cell monoclonality, Epstein Barr virus, and t(14;18) in myoepithelial sialadenitis and low-grade B-cell MALT lymphoma of the parotid gland. Am J Surg Pathol. 1995 May;19(5):531-6. PMID: #7726362#
Sundeen JT, Longo DL, Jaffe ES. CD5 expression in B-cell small lymphocytic malignancies. Correlations with clinical presentation and sites of disease. Am J Surg Pathol. 1992 Feb;16(2):130-7. PMID: #1370753#
Aozasa K. Malignant lymphoma of the mucosa-associated lymphoid tissue. Am J Surg Pathol. 1992 Jan;16(1):90-2. PMID: 1728201
Ladanyi M. Bcl-2 gene rearrangement in salivary gland lymphoma. Am J Surg Pathol. 1991 Aug;15(8):814. PMID: #2069217#
Falzon M, Isaacson PG. The natural history of benign lymphoepithelial lesion of the salivary gland in which there is a monoclonal population of B cells. A report of two cases. Am J Surg Pathol. 1991 Jan;15(1):59-65. PMID: #1898682#
Kerrigan DP, Irons J, Chen IM. bcl-2 gene rearrangement in salivary gland lymphoma. Am J Surg Pathol. 1990 Dec;14(12):1133-8. PMID: #2252103#
Isaacson PG, Spencer J. Monocytoid B-cell lymphomas. Am J Surg Pathol. 1990 Sep;14(9):888-91. PMID: #2389820#
Isaacson PG, Chan JK, Tang C, Addis BJ. Low-grade B-cell lymphoma of mucosa-associated lymphoid tissue arising in the thymus. A thymic lymphoma mimicking myoepithelial sialadenitis. Am J Surg Pathol. 1990 Apr;14(4):342-51. PMID: #1690952#