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mitochondrial DNA mutations in cancer
Monday 17 September 2007
Somatic mutations in mitochondrial DNA (mtDNA) have been demonstrated in various tumors.
Tumors
renal cell carcinomas (RCCs) breast cancer (16568452)
- It still remains unclear whether the alterations in mtDNA are related to the clinicopathological features and/or the prognosis in the breast cancer. (16568452)
- D-loop mutation is a significant marker that is independent of other clinical variables and that it can be used to assess the prognosis of patients. (16568452)
- Somatic mutations in mtDNA D-loop can be used as a new molecular prognostic indicator in breast cancer. (16568452)
See aslo
somatic mutations D-loop region copy number of mtDNA somatic mutations in mtDNA D-loop region
References
Tseng LM, Yin PH, Chi CW, Hsu CY, Wu CW, Lee LM, Wei YH, Lee HC. Mitochondrial DNA mutations and mitochondrial DNA depletion in breast cancer. Genes Chromosomes Cancer. 2006 Jul;45(7):629-38. PMID: 16568452